Document Detail

Prospective study of 310 patients: can early CT predict the severity of acute pancreatitis?
MedLine Citation:
PMID:  16944038     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was designed to determine the most important early CT parameters predictive of acute pancreatitis severity. METHODS: Three hundred and seventy-one consecutive patients with acute abdominal pain and hyperamylasemia were enrolled. Three hundred and ten of the 371 patients met our inclusion criteria. Acute pancreatitis severity was evaluated using the 1992 Atlanta criteria. Different CT parameters were reported from the admission abdominal CT by two radiologists blinded from any clinical parameter, but the patients' age and gender. These variables were fitted in a binary logistic regression model. RESULTS: Acute pancreatitis was mild in 80% cases, severe in 20% cases and lethal in 12.69% cases. The following CT parameters were significantly associated with the severity of acute pancreatitis: the objective size of the pancreas (P = 0.001), the peripancreatic fat abnormalities (P = 0.001) and the extent of necrosis (P = 0.007). Moreover, the age of the patient revealed itself a highly significant (P = 0.001) indicator of disease severity. The association of the four CT criteria eventually showed a sensitivity of 73% and a specificity of 81% to predict acute pancreatitis severity. CONCLUSION: Although these criteria correlated with disease severity, our study identified that morphological CT criteria cannot be used to triage patients with severe and mild acute pancreatitis.
A-S Knoepfli; K Kinkel; T Berney; P Morel; C D Becker; P-A Poletti
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Publication Detail:
Type:  Journal Article     Date:  2006-08-31
Journal Detail:
Title:  Abdominal imaging     Volume:  32     ISSN:  0942-8925     ISO Abbreviation:  Abdom Imaging     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9303672     Medline TA:  Abdom Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-5     Citation Subset:  IM    
Department of Radiology, Geneva University Hospital, Geneva, Switzerland.
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MeSH Terms
Abdominal Pain / radiography
Acute Disease
Age Factors
Aged, 80 and over
Early Diagnosis
Hyperamylasemia / radiography
Intra-Abdominal Fat / radiography
Middle Aged
Organ Size
Pancreas / radiography
Pancreatitis / classification*,  radiography
Pancreatitis, Acute Necrotizing / radiography
Prospective Studies
Sensitivity and Specificity
Severity of Illness Index
Single-Blind Method
Tomography, X-Ray Computed / methods*
Comment In:
Abdom Imaging. 2007 Mar-Apr;32(2):265-6   [PMID:  17435983 ]

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