Document Detail

Prospective randomized trial to evaluate the efficacy of a vaginal ring releasing progesterone for IVF and oocyte donation.
MedLine Citation:
PMID:  11006179     Owner:  NLM     Status:  MEDLINE    
A polysyloxane vaginal ring containing 1g of natural progesterone was developed as luteal supplementation for women treated with IVF-embryo transfer and for agonadal women participating in an oocyte donation programme. The ring provides continuous release of progesterone (10-20 nmol/l) for 90 days. The efficacy of this form of progesterone supplementation was evaluated in two multicentre prospective randomized trials. IVF-embryo transfer trial: After oocyte aspiration, 505 women were randomly allocated to progesterone supplementation with vaginal ring or i.m. progesterone (50 mg/day). The clinical pregnancy rate was 36.6% in both groups. Implantation rate was 15.9% in the vaginal ring and 16.0% in i.m. progesterone. Oocyte donation trial: After endometrial proliferation with micronized oestradiol, 153 women were allocated to progesterone replacement with a vaginal ring or i.m. progesterone (100 mg/day). Clinical pregnancy rate was 39.8 and 28.6% respectively. Implantation rate was significantly higher with the vaginal ring compared with i.m. progesterone (19.9 and 11.6% respectively, P = 0.006). The vaginal ring is a novel development which provides continuous release of progesterone for 90 days. In IVF-embryo transfer, its effectiveness is similar to daily i.m. injections. In oocyte donation the ring provides a progestative milieu which improves the implantation rate and eliminates the discomfort of daily i.m. injections.
F Zegers-Hochschild; J P Balmaceda; C Fabres; V Alam; A Mackenna; E Fernández; I M Pacheco; M S Sepúlveda; S Chen; C Borrero; E Borges
Related Documents :
11006179 - Prospective randomized trial to evaluate the efficacy of a vaginal ring releasing proge...
21289749 - Exercise and pregnancy.
8982719 - Turnover rate and stimulus-evoked release of dopamine by progesterone and n-methyl-d-as...
23532169 - Evaluation of the impact of gonadotropin-releasing hormone agonist as an adjuvant in lu...
19747959 - Progesterone regulation of primordial follicle assembly in bovine fetal ovaries.
21449899 - Paediatricians' knowledge, attitudes and practice following provision of educational re...
2598909 - Incidence and some perinatal problems of multiple pregnancies in a central referral hos...
17060879 - Effect of pregnancy on pre-existing liver disease physiological changes during pregnancy.
22255679 - Computerized intrapartum electronic fetal monitoring: analysis of the decision to deliv...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-13     Completed Date:  2000-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2093-7     Citation Subset:  IM    
Unidad de Medicina Reproductiva, Clínica Las Condes, Santiago, Chile.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Drug Delivery Systems*
Embryo Implantation
Fertilization in Vitro / methods*
Oocyte Donation*
Ovulation Induction
Pregnancy Outcome
Pregnancy Rate
Progesterone / administration & dosage*
Prospective Studies
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of alendronate and hormone replacement therapy, alone or in combination, on bone mass in pos...
Next Document:  Prediction models for insulin resistance in the polycystic ovary syndrome.