Document Detail


Prospective randomized trial to evaluate the efficacy of a vaginal ring releasing progesterone for IVF and oocyte donation.
MedLine Citation:
PMID:  11006179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A polysyloxane vaginal ring containing 1g of natural progesterone was developed as luteal supplementation for women treated with IVF-embryo transfer and for agonadal women participating in an oocyte donation programme. The ring provides continuous release of progesterone (10-20 nmol/l) for 90 days. The efficacy of this form of progesterone supplementation was evaluated in two multicentre prospective randomized trials. IVF-embryo transfer trial: After oocyte aspiration, 505 women were randomly allocated to progesterone supplementation with vaginal ring or i.m. progesterone (50 mg/day). The clinical pregnancy rate was 36.6% in both groups. Implantation rate was 15.9% in the vaginal ring and 16.0% in i.m. progesterone. Oocyte donation trial: After endometrial proliferation with micronized oestradiol, 153 women were allocated to progesterone replacement with a vaginal ring or i.m. progesterone (100 mg/day). Clinical pregnancy rate was 39.8 and 28.6% respectively. Implantation rate was significantly higher with the vaginal ring compared with i.m. progesterone (19.9 and 11.6% respectively, P = 0.006). The vaginal ring is a novel development which provides continuous release of progesterone for 90 days. In IVF-embryo transfer, its effectiveness is similar to daily i.m. injections. In oocyte donation the ring provides a progestative milieu which improves the implantation rate and eliminates the discomfort of daily i.m. injections.
Authors:
F Zegers-Hochschild; J P Balmaceda; C Fabres; V Alam; A Mackenna; E Fernández; I M Pacheco; M S Sepúlveda; S Chen; C Borrero; E Borges
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-13     Completed Date:  2000-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2093-7     Citation Subset:  IM    
Affiliation:
Unidad de Medicina Reproductiva, Clínica Las Condes, Santiago, Chile. umrclc@entelchile.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Drug Delivery Systems*
Embryo Implantation
Female
Fertilization in Vitro / methods*
Humans
Injections
Oocyte Donation*
Ovulation Induction
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Progesterone / administration & dosage*
Prospective Studies
Vagina
Chemical
Reg. No./Substance:
57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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