Document Detail

Prospective randomized study comparing amoxicillin-clavulanic acid with cefazolin as antimicrobial prophylaxis in laparotomic gynecologic surgery.
MedLine Citation:
PMID:  14616259     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To compare amoxicillin-clavulanic acid with cefazolin as ultra-short-term prophylaxis in laparotomic gynecologic surgery. MATERIALS AND METHODS: A prospective randomized study was conducted to compare two antimicrobial regimens in surgical prophylaxis of laparotomic surgery. Patients were randomly allocated to receive amoxicillin-clavulanic acid (2.2 g) [Group A] or cefazolin (2 g) [Group B] as a single dose 30 min before surgery. Each patient was assessed daily until discharge to evidence febrile status and the presence of infections at the operative site, urinary tract, and respiratory tract. RESULTS: In the amoxicillin-clavulanic acid (Group A) and cefazolin (Group B) groups, overall 346 and 352 patients, respectively, were evaluable for prophylactic efficacy at hospital discharge. Infectious complications were infrequent in both arms. Febrile morbidity occurred in 21 (6.1%) and 26 (7.4%) patients, respectively, in the amoxicillin-clavulanic acid and cefazolin groups. Wound infection and urinary tract infection were also higher, but not significantly in the cefazolin group (0.5% vs. 1.1% and 2.0% vs. 2.5%, respectively). There was one respiratory tract infection (0.2%) in Group B, and no septic death in either groups. CONCLUSION: Ultra-short-term prophylaxis with both amoxicillin-clavulanic acid and cefazolin is safe in elective laparotomic gynecologic surgery.
Gennaro Cormio; Franco Di Fazio; Cinzia Cacciapuoti; Stefano Bettocchi; Luisella Borraccino; Luigi Selvaggi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  82     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1130-4     Citation Subset:  IM    
Sezione di Ginecologia A, Dipartimento di Scienze Chirurgiche Generali e Specialistiche, Università degli Studi di Bari, Italy.
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MeSH Terms
Aged, 80 and over
Amoxicillin-Potassium Clavulanate Combination / administration & dosage*
Antibiotic Prophylaxis*
Cefazolin / administration & dosage*
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Genital Diseases, Female / diagnosis,  surgery
Gynecologic Surgical Procedures / adverse effects,  methods
Laparotomy / adverse effects*,  methods
Middle Aged
Postoperative Complications / prevention & control*
Preoperative Care / methods
Prospective Studies
Risk Assessment
Surgical Wound Infection / prevention & control
Treatment Outcome
Reg. No./Substance:
25953-19-9/Cefazolin; 74469-00-4/Amoxicillin-Potassium Clavulanate Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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