Document Detail

Prospective randomized double-blind trial of neurolytic coeliac plexus block in patients with pancreatic cancer.
MedLine Citation:
PMID:  9501815     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In a randomized double-blind study the efficacy of neurolytic coeliac plexus block (NCPB) was compared with pharmacological therapy in the treatment of pain from pancreatic cancer. METHODS: Twenty-four patients were divided into two groups: 12 patients underwent NCPB (group 1) and 12 were treated with pharmacological therapy (group 2). Immediate and long-term efficacy, mean analgesic consumption, mortality and morbidity were evaluated at follow-up. Statistical analysis was performed with the unpaired t test, Mann-Whitney U test and Fisher's exact test. RESULTS: Immediately after the block, patients in group 1 reported significant pain relief compared with those in group 2 (P < 0.05), but long-term results did not differ between the groups. Mean analgesic consumption was lower in group 1. There were no deaths. Complications related to NCPB were transient diarrhoea and hypotension (P not significant between groups). Drug-related adverse effects were constipation (five of 12 patients in group 1 versus 12 of 12 in group 2), nausea and/or vomiting (four of 12 patients in group 1 versus 12 of 12 in group 2) (P < 0.05), one gastric ulcer and one gluteal abscess in group 2. CONCLUSION: NCPB was associated with a reduction in analgesic drug administration and drug-related adverse effects, representing an effective tool in the treatment of pancreatic cancer pain.
E Polati; G Finco; L Gottin; C Bassi; P Pederzoli; S Ischia
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of surgery     Volume:  85     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  199-201     Citation Subset:  AIM; IM    
Institute of Anaesthesiology and Intensive Care, University of Verona, Italy.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects,  therapeutic use
Autonomic Nerve Block / methods*
Celiac Plexus*
Diclofenac / adverse effects,  therapeutic use
Double-Blind Method
Follow-Up Studies
Middle Aged
Narcotics / adverse effects,  therapeutic use
Pain / prevention & control*
Pain Measurement
Pain, Postoperative / etiology
Pancreatic Neoplasms*
Prospective Studies
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Narcotics; 15307-86-5/Diclofenac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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