Document Detail

Prospective, randomized, controlled trial of a hemostatic sealant in children undergoing adenotonsillectomy.
MedLine Citation:
PMID:  17765775     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the efficacy of Floseal as a hemostatic sealant compared to traditional electrocautery hemostasis after cold knife adenotonsillectomy. STUDY DESIGN: Prospective, randomized, controlled trial of 68 consecutive patients undergoing cold steel adenotonsillectomy. Patients were randomized to receive either Floseal (FS) or electrocautery (EC) for hemostasis. RESULTS: FS patients had shorter operative times than EC patients (16 min vs 31.2 min, P < 0.0001) and less blood loss (49.2 mL vs 70.8 mL, P < 0.05). Four EC patients were crossed over to Floseal when adequate hemostasis could not be achieved in the adenoid bed. No Floseal patients were crossed over. FS patients had significantly less pain on postoperative days two through 11 (P < 0.05) and less use of narcotic pain medications over the first 10 postoperative days (P < 0.05). FS patients also had a faster return to regular diet (5.5 days vs 7.9 days, P < 0.01) and activity (5.3 days vs 7.8 days, P < 0.01) as compared to the EC patients. There were no significant complications in either group. CONCLUSIONS: Floseal is safe and efficacious, and decreases postoperative morbidity as compared to electrocautery hemostasis after cold steel adenotonsillectomy. SIGNIFICANCE: This study demonstrates the safety and efficacy of Floseal as a hemostatic method in children undergoing adenotonsillectomy.
Stephen H Jo; Ronald A Mathiasen; Deepak Gurushanthaiah
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  137     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  454-8     Citation Subset:  IM    
Head and Neck Surgery Department, Kaiser Permanente Medical Center, Oakland, CA 94611, USA.
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MeSH Terms
Adenoidectomy / adverse effects*
Blood Loss, Surgical / prevention & control*
Child, Preschool
Cost-Benefit Analysis
Gelatin Sponge, Absorbable / economics,  therapeutic use*
Hemostasis, Surgical / economics,  methods*
Hemostatics / economics,  therapeutic use*
Pharyngeal Diseases / surgery
Prospective Studies
Recovery of Function
Tonsillectomy / adverse effects*
Treatment Outcome
Reg. No./Substance:
0/FloSeal Matrix; 0/Hemostatics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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