| Prospective randomized comparison of sodium tetradecyl sulfate and polidocanol as variceal sclerosing agents. | |
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MedLine Citation:
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PMID: 1734694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective randomized controlled study was designed to evaluate differences in efficacy and complication rate between the two most commonly used sclerosing agents, sodium tetradecyl sulfate (STD) and polidocanol. Of 52 patients with esophageal variceal bleeding, 26 were randomized to receive sclerotherapy with 1.5% STD and 26 to receive 1% polidocanol at weekly intervals. Eradication of varices was achieved in 88% patients each of the STD and polidocanol group. There was no significant difference between patients injected with STD and polidocanol with regard to re-bleeding (27% vs. 15%) and mortality (11.5% in both). The use of STD, in contrast to polidocanol, was associated with a higher incidence of complications in terms of severe retrosternal pain (27% vs. 4%), deep ulceration (53% vs. 23%), dysphagia (88% vs. 46%), and stricture formation (27% vs. 8%). It was concluded that these two agents were similar in efficacy. However, polidocanol was superior due to a lower incidence of complications. |
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Authors:
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D K Bhargava; B Singh; R Dogra; S Dasarathy; M P Sharma |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 87 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-05 Completed Date: 1992-03-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 182-6 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Drug Evaluation Esophageal and Gastric Varices / complications* Female Gastrointestinal Hemorrhage / etiology, therapy* Humans Male Middle Aged Polyethylene Glycols / therapeutic use* Recurrence Sclerosing Solutions / therapeutic use* Sclerotherapy / adverse effects, methods* Sodium Tetradecyl Sulfate / therapeutic use* Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Polyethylene Glycols; 0/Sclerosing Solutions; 1191-50-0/Sodium Tetradecyl Sulfate; 9002-92-0/polidocanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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