| Prospective randomized clinical trial assessing the efficacy of a short course of intravenously administered amoxicillin plus clavulanic acid followed by oral antibiotic in patients with uncomplicated acute diverticulitis. | |
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MedLine Citation:
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PMID: 20526718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Medical treatment of uncomplicated acute diverticulitis is not standardized, and there is an enormous diversity in clinical practice. Our aim was to demonstrate that uncomplicated diverticulitis can be managed with orally administered amoxicillin plus clavulanic acid and a short hospital admission. METHODS: A prospective randomized trial was established to compare patients with uncomplicated diverticulitis who received oral antibiotic after a short course of intravenous antibiotic with those who received intravenous antibiotic for a longer period. The antibiotic treatment consisted of amoxicillin plus clavulanic acid 1 g every 8 h. We included 50 patients, 25 in each group. Patients in group 1 began oral antibiotic as soon as they improved and were discharged the day after. Patients in group 2 received intravenous antibiotic for 7 days. Both groups received oral antibiotic at discharge. The endpoint of the study was "failure of treatment," which was defined as the impossibility of discharging on the expected day, emergency admission, or hospital readmission. RESULTS: Both groups were comparable in patient demographics and clinical characteristics. Most patients clearly improved between 24 and 48 h after admission. There were no significant differences between the groups when comparing failure of treatment. Treatment of patients in group 1 represented a savings in hospitalization costs of 1,244<euro> per patient. CONCLUSIONS: Most patients with uncomplicated diverticulitis can be managed safely with oral antibiotic; thus, a very short hospital stay is a safe option. |
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Authors:
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Yolanda Ribas; Jordi Bombardó; Francesc Aguilar; Esther Jovell; Manel Alcantara-Moral; Francesc Campillo; Xavier Lleonart; Xavier Serra-Aracil |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-06-05 |
Journal Detail:
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Title: International journal of colorectal disease Volume: 25 ISSN: 1432-1262 ISO Abbreviation: Int J Colorectal Dis Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-29 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607899 Medline TA: Int J Colorectal Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 1363-70 Citation Subset: IM |
Affiliation:
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Department of Surgery, Consorci Sanitari de Terrassa, Carretera de Torrebonica s/n, Terrassa, Spain. ribas.yolanda@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Oral Amoxicillin / administration & dosage*, therapeutic use* Anti-Bacterial Agents / administration & dosage*, therapeutic use* Clavulanic Acid / administration & dosage*, therapeutic use* Demography Diverticulitis / drug therapy* Drug Therapy, Combination Female Humans Injections, Intravenous Male Middle Aged Patient Admission Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 26787-78-0/Amoxicillin; 58001-44-8/Clavulanic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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