Document Detail


Prospective quality of life assessment between treatment groups for oral cavity squamous cell carcinoma.
MedLine Citation:
PMID:  23720248     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Postoperative radiation therapy (PORT) is frequently recommended to improve survival outcome. The effect of PORT-associated morbidity on patients' quality of life (QOL) is, however, not well established. This study assesses the effect of PORT on medium-term, i.e., at 6 months, QOL in patients with oral cavity squamous cell carcinoma. METHODS: Patient completed the EORTC QLQ-C30 and QLQ-H&N35 questionnaires at initial presentation, and at three, six and twelve months follow-up. Baseline QOL scores were adjusted for using analysis of covariance. RESULTS: Global health status (mean difference=13.3, p=0.042) and xerostomia (mean difference=35.4, p=0.003) were significantly worse at 6 months in patients who received PORT compared to those treated with surgery alone. CONCLUSION: The survival advantage needs to be balanced against increased treatment toxicity. PORT is associated with reduced global health status, increased xerostomia and marginally increased levels of fatigue at 6 months post treatment for oral cavity cancer. © 2013 Wiley Periodicals, Inc. Head Neck, 2013.
Authors:
S Ch'ng; J Oates; K Gao; Kerwyn Foo; Sarah Davies; M Brunner; J R Clark
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-29
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.
Affiliation:
Sydney Head & Neck Cancer Institute, Royal Prince Alfred Hospital, Missenden Road Camperdown 2050, Sydney, New South Wales, Australia.
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