Document Detail

Prospective prenatal serum screening for Down syndrome in Venezuela.
MedLine Citation:
PMID:  18817910     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the usefulness of triple-marker screening for Down syndrome in Venezuela. METHOD: Maternal serum concentrations of alpha fetoprotein (AFP), beta human chorionic gonadotropin (beta-hCG), and unconjugated estriol (uE3) were measured weekly in 3895 women from the 15th to the 20th week of pregnancy. Population-specific likelihood ratios were determined and used to calculate the risk of fetal Down syndrome for each pregnancy. RESULTS: The median multiple of the median values for AFP, beta-hCG, and uE3 concentrations were 0.69, 2.10, and 0.67 for the affected pregnancies. The likelihood ratio for a positive result was 1:19. The detection and false-positive rates were 69.23% and 5.8%. CONCLUSION: These findings were consistent with reported data and therefore confirmed triple-marker serum screening as effective and suitable for prenatal care in Venezuela. Latin American governments and Health Agencies should recommend offering this screening method to all pregnant women.
Francisco Alvarez-Nava; Marisol Soto; Alisandra Morales-Machín; Alicia Rojas; Karelis Urdaneta; Jenny Cañizález
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-25
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  103     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
Unidad de Genética Médica, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
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MeSH Terms
Biological Markers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood*
Down Syndrome / blood,  diagnosis*,  epidemiology
Estriol / blood*,  diagnostic use
False Positive Reactions
Logistic Models
Maternal Age
Predictive Value of Tests
Pregnancy Trimester, Second
Prenatal Diagnosis / methods*
Prospective Studies
Reference Values
Risk Factors
Statistics, Nonparametric
Venezuela / epidemiology
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins; 50-27-1/Estriol

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