Document Detail


Prospective optical coherence tomographic evaluation of the efficacy of oral and posterior subtenon corticosteroids in patients with intermediate uveitis.
MedLine Citation:
PMID:  16896918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To prospectively evaluate the efficacy of oral corticosteroids and posterior subtenon injection in the treatment of macular edema in patients with intermediate uveitis using optical coherence tomography (OCT). METHODS: Twenty-two patients with intermediate uveitis were treated with posterior subtenon injection when the disease was unilateral (group A, n=11) or with oral steroids when the disease was bilateral (group B, n=11). Changes in macular thickness from baseline was determined using OCT in both groups at day 0, day 3, day 14, 6 weeks and 12 weeks. RESULTS: Statistically significant improvement in Snellen visual acuity in group A was seen at 6 weeks and in group B at 2 weeks. In patients receiving oral corticosteroids, foveal thickness decreased by 63% by day 3. In those treated with posterior subtenon injection, even at day 14 only a 55% reduction of foveal thickness was evident. Spearman's correlation coefficient for visual acuity and foveal thickness was found to be significant. CONCLUSION: OCT confirms a significantly more rapid decrease in macular edema in patients treated with oral corticosteroids. A short course of oral steroids may be useful in enabling earlier visual recovery in patients treated with posterior subtenon injection for unilateral uveitic macular edema.
Authors:
Pradeep Venkatesh; Zaheer Abhas; Satpal Garg; Rajpal Vohra
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-08-02
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  245     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-01     Completed Date:  2007-11-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  59-67     Citation Subset:  IM    
Affiliation:
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. venkyprao@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Administration, Topical
Adult
Betamethasone / administration & dosage*
Connective Tissue
Drug Administration Routes
Female
Glucocorticoids / administration & dosage*
Humans
Injections
Macular Edema / diagnosis,  drug therapy*,  etiology
Male
Prednisolone / administration & dosage*
Prospective Studies
Tomography, Optical Coherence*
Treatment Outcome
Triamcinolone Acetonide / administration & dosage*
Uveitis, Intermediate / complications,  diagnosis,  drug therapy*
Visual Acuity / drug effects
Chemical
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone; 50-24-8/Prednisolone; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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