Document Detail

Prospective observations of 100 high-risk neonates by high-field (1.5 Tesla) magnetic resonance imaging of the central nervous system. II. Lesions associated with hypoxic-ischemic encephalopathy.
MedLine Citation:
PMID:  2011418     Owner:  NLM     Status:  MEDLINE    
One hundred neonates determined prospectively to be at risk for neurologic handicap underwent magnetic resonance imaging with a high-field (1.5 T) imager. Thirty-three demonstrated a total of 37 lesions consistent with hypoxic-ischemic encephalopathy, including periventricular leukomalacia (n = 12), basal ganglia hemorrhage (n = 5), multicystic encephalomalacia (n = 5), and focal parenchymal hemorrhage (n = 15). Diagnoses by ultrasonography and computed tomography were compared with those by magnetic resonance imaging in 29 and 17 infants, respectively. Ultrasonography agreed more frequently with magnetic resonance imaging than did computed tomography. Ultrasonography detected 79% of lesions demonstrated by magnetic resonance imaging whereas computed tomography detected only 41%. Periventricular leukomalacia was seen most often in preterm infants, basal ganglia hemorrhage and multicystic encephalomalacia primarily occurred in term infants, and focal parenchymal hemorrhage occurred at all gestational ages. Basal ganglia hemorrhage and multicystic encephalomalacia were strongly associated with histories of perinatal asphyxia, seizures, and early abnormal neurological status. All infants with basal ganglia hemorrhage (5/5) and multicystic encephalomalacia (5/5) and the majority with periventricular leukomalacia (9/12) and focal parenchymal hemorrhages (9/15) had developmental abnormalities at discharge.
S E Keeney; E W Adcock; C B McArdle
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  87     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-07     Completed Date:  1991-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-8     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Texas Medical School, Houston.
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MeSH Terms
Brain Ischemia / diagnosis*,  radiography,  ultrasonography
Cerebral Hemorrhage / diagnosis*,  radiography,  ultrasonography
Encephalomalacia / diagnosis*,  radiography,  ultrasonography
Infant, Newborn
Leukomalacia, Periventricular / diagnosis,  radiography,  ultrasonography
Magnetic Resonance Imaging / methods*
Prospective Studies
Risk Factors
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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