Document Detail

Prospective multinational study of pertussis infection in hospitalized infants and their household contacts.
MedLine Citation:
PMID:  17484221     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increased incidence of pertussis has been noted among infants too young to be immunized. We studied the disease burden of pertussis in pediatric intensive care units and the source of infection in several Asian, European and Latin American countries. METHODS: The study was conducted in 7 countries from September 2001 to January 2004. Children <1 year of age were enrolled from pediatric intensive care units (PICU) and pediatric wards if they presented with respiratory failure, apnea, bradycardia, or cough accompanied by paroxysms, vomiting, whoop or cyanosis. Household members of pertussis-positive index cases were asked to answer a questionnaire and provide diagnostic specimens. RESULTS: Pertussis was confirmed in 99 infants (12%) of 823 infants included in the analysis: 10 of 90 (11%) in Brazil, 9 of 88 (10%) in Costa Rica, 11 of 145 (8%) in Germany, 13 of 147 (9%) in Singapore, 29 of 67 (43%) in Spain, 2 of 86 (2%) in Taiwan and 25 of 200 (13%) in Uruguay. However, sensitivity analysis indicated that these figures were conservative. The mean (+/- SD) average age of infection was 2.6 +/- 2.2 months. Pertussis was found among 96 of 269 (36%) of household contacts investigated. At least one household contact was identified as the source of infection in 24 of 88 (27%) of the PICU cases and mothers were identified as being the most frequent source of infection. CONCLUSION: Although regional differences exist, severe pertussis represents a considerable global disease burden. Since most infants are infected before vaccination and concomitant protection is completed, household contacts should be targeted for booster vaccination to reduce the pertussis reservoir.
Frank Kowalzik; Arnaldo Prata Barbosa; Vera Regina Fernandes; Paulo Roberto Carvalho; Maria Luisa Avila-Aguero; Daniel Y T Goh; Anne Goh; Jesus Garcia de Miguel; Fernando Moraga; Joan Roca; Magda Campins; Ming Huang; Jorge Quian; Nicole Riley; Dominique Beck; Thomas Verstraeten
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  26     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-42     Citation Subset:  IM    
University of Mainz, Mainz, Germany.
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MeSH Terms
Brazil / epidemiology
Contact Tracing*
Costa Rica / epidemiology
Family Characteristics
Germany / epidemiology
Infant, Newborn
Singapore / epidemiology
Spain / epidemiology
Taiwan / epidemiology
Uruguay / epidemiology
Whooping Cough / epidemiology*

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