Document Detail


Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy.
MedLine Citation:
PMID:  19967618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND STUDY AIMS: A second-generation capsule endoscopy system, using the PillCam Colon 2, was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. The performance of this new system is reported. PATIENTS AND METHODS: In a five-center feasibility study, second-generation capsule endoscopy was prospectively compared with conventional colonoscopy as gold standard for the detection of colorectal polyps and other colonic disease, in a cohort of patients scheduled for colonoscopy and having known or suspected colonic disease. Colonoscopy was independently performed within 10 hours after capsule ingestion. Capsule-positive but colonoscopy-negative cases were counted as false-positive. RESULTS: 104 patients (mean age 49.8 years) were enrolled; data from 98 were analyzed. Patient rate for polyps of any size was 44 %, 53 % of these patients having adenomas. No adverse events related to either procedure were reported. The capsule sensitivity for the detection of patients with polyps >or= 6 mm was 89 % (95 % confidence interval [CI] 70 - 97) and for those with polyps >or= 10 mm it was 88 % (95 %CI 56 - 98), with specificities of 76 % (95 %CI 72 - 78) and 89 % (95 %CI 86 - 90), respectively. Both polyps missed by colonoscopy and mismatch in polyp size by study definition lowered specificity. Overall colon cleanliness for capsule endoscopy was adequate in 78 % of patients (95 %CI 68 - 86). CONCLUSIONS: The new second-generation colon capsule endoscopy is a safe and effective method for visualizing the colon and detecting colonic lesions. Sensitivity and specificity for detecting colorectal polyps appear to be very good, suggesting a potential for improved accuracy compared with the first-generation system. Further prospective and comparative studies are needed.
Authors:
R Eliakim; K Yassin; Y Niv; Y Metzger; J Lachter; E Gal; B Sapoznikov; F Konikoff; G Leichtmann; Z Fireman; Y Kopelman; S N Adler
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-12-04
Journal Detail:
Title:  Endoscopy     Volume:  41     ISSN:  1438-8812     ISO Abbreviation:  Endoscopy     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-01     Revised Date:  2010-04-28    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1026-31     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart New York.
Affiliation:
Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel. r_eliakim@rambam.health.gov.il
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Capsule Endoscopy*
Cathartics / administration & dosage
Colonic Polyps / diagnosis*
Colonoscopy*
False Positive Reactions
Feasibility Studies
Female
Humans
Male
Middle Aged
Phosphates / administration & dosage
Polyethylene Glycols / administration & dosage
Sensitivity and Specificity
Young Adult
Chemical
Reg. No./Substance:
0/Cathartics; 0/Phosphates; 0/Polyethylene Glycols; 7632-05-5/sodium phosphate
Comments/Corrections
Comment In:
Endoscopy. 2010 May;42(5):427-8; author reply 428   [PMID:  20425668 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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