| Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly. | |
| | |
MedLine Citation:
|
PMID: 23153984 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Prognostic values of N-terminal pro-brain natriuretic peptide (NT-proBNP) in myriad diseases have been studied. During the natural progression of atherosclerotic renal artery disease (ARVD) changes of NT-proBNP levels and its significance is not understood. A prospective longitudinal follow-up study was conducted among 61 ARVD patients (77.7±5.2 years old). NT-proBNP was determined at baseline and six month intervals over 25.89±12.44 months and its correlation with death and/or newly occurred CVEs were assessed. Level of NT-proBNP increased from baseline median 210.0pg/mL (25th-75th percentile, 98.0pg/mL-540.0pg/mL) to 900.9pg/mL (25th-75th percentile, 704.5pg/mL-1583.5pg/mL) (p=0.032) at the end of follow-up. Among 44.26% of the cohort (n=27) NT-proBNP level ≥450pg/mL was detected, which 6 deaths happened (22.22% death rate) and CVEs occurred to 62.96% of patients, comparing to 0% death rate (p=0.077) and 8.82% affected by CVEs (p=0.019) in other 55.74% of cohort (n=34) whose NT-proBNP <450pg/mL. Kaplan-Meier analysis showed that NT-proBNP level ≥450pg/mL was a risk factor related to CVEs (HR=3.96, p=0.03). Cox regression analysis found NT-proBNP level ≥450pg/mL was an independent risk factor of CVEs (HR=5.12, p=0.022) after adjustment of body mass index, blood pressure, kidney function. The negative predictive value was 90.9% of NT-proBNP levels ≥450pg/mL for new CVEs. NT-proBNP levels diverge throughout ARVD natural progression in elderly males over 75 years of age. Elevated NT-proBNP level of ≥450pg/mL was predictive for CVEs with 90.9% of negative predictive value. |
| | |
Authors:
|
Qiwei Zhu; Ningyu An; Yongyi Bai; Ning Zhu; Meihua Li |
Related Documents
:
|
18303224 - Effect of laser spot diameter on the reproducibility of visual field analysis in diabet... 1454304 - Anisometropic amblyopia: is the patient ever too old to treat? 16996614 - Primary treatment of acute retinal necrosis with oral antiviral therapy. 19243834 - Verteporfin photodynamic therapy combined with intravitreal bevacizumab for neovascular... 14648104 - The role of interventional radiology in biliary complications after orthotopic liver tr... 485184 - Combination therapy for psoriasis. psoralens plus long-wave ultraviolet radiation with ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-12 |
Journal Detail:
|
Title: Archives of gerontology and geriatrics Volume: - ISSN: 1872-6976 ISO Abbreviation: Arch Gerontol Geriatr Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8214379 Medline TA: Arch Gerontol Geriatr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Second Division of Geriatric Cardiology, Chinese PLA General Hospital, 28th Fuxing Road, Beijing 100853, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Visfatin and its role in obesity development.
Next Document: Gender differences in factors influencing sexual satisfaction in Korean older adults.