| Prospective medical assessment of adults surviving childhood cancer: study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort study. | |
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MedLine Citation:
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PMID: 21370418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To facilitate prospective medical assessment of adults surviving pediatric malignancies and advance knowledge about long-term childhood cancer survivor health, St. Jude Children's Research Hospital (SJCRH) is establishing a lifetime cohort of survivors. METHODS: Eligibility criteria for inclusion in the St. Jude Lifetime Cohort (SJLIFE) study include: (1) diagnosis of childhood malignancy treated at SJCRH; (2) survival ≥ 10 years from diagnosis; and (3) current age ≥ 18 years. Three levels of participation are offered: (1) comprehensive evaluation on SJCRH campus; (2) limited home evaluation; or (3) completion of health surveys only. A systematic recruitment structure based upon blocks of 50 patients initially focused on leukemia and lymphoma survivors and patients eligible for pilot studies. RESULTS: As of January 1, 2010, 1,625 (42%) of 3,900 eligible ≥ 10-year survivors have been contacted. Among the first 1,000 potentially eligible survivors selected for recruitment, 971 were subsequently confirmed to fulfill eligibility criteria. To date, 898/971 (92.5%) have been successfully contacted of whom 825 (91.8%) have agreed to participate. Among participants, 88.6% agreed to comprehensive medical evaluation, 0.4% limited local evaluation, and 11.0% survey only. Anticipated minimum overall participation rate for medical evaluation is 75.3% (731/971). Comparison of those contacted who agreed versus declined to participate revealed a greater proportion of males who declined participation (P = 0.001). CONCLUSIONS: Early results of the SJLIFE study support its feasibility to recruit aging childhood cancer survivors to research investigations evaluating late health outcomes by medical assessments. |
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Authors:
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Melissa M Hudson; Kirsten K Ness; Vikki G Nolan; Gregory T Armstrong; Daniel M Green; E Brannon Morris; Sheri L Spunt; Monika L Metzger; Kevin R Krull; James L Klosky; Deo Kumar Srivastava; Leslie L Robison |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-15 |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 56 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-03-03 Completed Date: 2011-05-26 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 825-36 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Oncology, Division of Cancer Survivorship, St. Jude Children's Research Hospital and The University of Tennessee College of Medicine, Memphis, Tennessee, USA. melissa.hudson@stjude.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cohort Studies Feasibility Studies Female Follow-Up Studies Health Status* Humans Longitudinal Studies Male Middle Aged Neoplasms / mortality*, psychology* Prognosis Prospective Studies Quality of Life* Research Design* Risk Factors Survival Rate Survivors* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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CA 21765/CA/NCI NIH HHS; P30 CA021765-28/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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