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Prospective longitudinal study of corneal collagen crosslinking in progressive keratoconus.
MedLine Citation:
PMID:  23145528     Owner:  NLM     Status:  Publisher    
BACKGROUND: Collagen crosslinking has been reported to be effective in treating progressive keratoconus and this study aims to evaluate the long term efficacy of this procedure. DESIGN: Prospective longitudinal interventional study of patients with progressive keratoconus who underwent crosslinking in a tertiary referral hospital. PARTICIPANTS: Thirty five patients (fifty one eyes) who underwent crosslinking with a mean follow up of 14.38 + 9.36 months (range 6 - 48) were compared with a control group of twenty five fellow eyes that did not undergo the procedure. METHODS: Crosslinking was performed using 0.1% riboflavin (in 20% dextran T500) and ultraviolet A irradiation (370 nm, 3mW/cm(2) ,30 minutes). MAIN OUTCOME MEASURES: Maximum keratometry in dioptres (D), logMAR best spectacle corrected visual acuity , cylindrical power, manifest refraction spherical equivalent and central corneal thickness. RESULTS: Analysis of the treated group demonstrated a significant flattening of maximum keratometry by 0.96 + 2.33 D (p = 0.005) and a significant improvement in visual acuity by 0.05 + 0.13 logMAR (p = 0.04). In the control group, maximum keratometry increased significantly by 0.43 + 0.85 D (p = 0.05) and visual acuity decreased by mean 0.05 + 0.14 (p = 0.2). No statistical differences were noted regarding cylindrical power, spherical equivalent or corneal thickness in both groups. CONCLUSIONS: Results indicate that corneal collagen crosslinking using riboflavin and ultraviolet-A is effective as a therapeutic option in cases of progressive keratoconus by reducing the corneal curvature and improving the visual acuity in these patients.
Deepa Viswanathan; John Males
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  -     ISSN:  1442-9071     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Australian School of Advanced Medicine, Macquarie University, Sydney, Australia.
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