Document Detail

Prospective longitudinal evaluation of lung function during the first year of life after extracorporeal membrane oxygenation.
MedLine Citation:
PMID:  20581733     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : To collect longitudinal data on lung function in the first year of life after extracorporeal membrane oxygenation and to evaluate relationships between lung function and perinatal factors. Longitudinal data on lung function in the first year of life after extracorporeal membrane oxygenation are lacking.
DESIGN: : Prospective longitudinal cohort study.
SETTING: : Outpatient clinic of a tertiary level pediatric hospital.
PATIENTS: : The cohort consisted of 64 infants; 33 received extracorporeal membrane oxygenation for meconium aspiration syndrome, 14 for congenital diaphragmatic hernia, four for sepsis, six for persistent pulmonary hypertension of the neonate, and seven for respiratory distress syndrome of infancy. Evaluation was at 6 mos and 12 mos; 39 infants were evaluated at both time points.
MEASUREMENTS AND MAIN RESULTS: : Functional residual capacity and forced expiratory flow at functional residual capacity were measured and expressed as z score. Mean (sem) functional residual capacities in z score were 0.0 (0.2) and 0.2 (0.2) at 6 mos and 12 mos, respectively. Mean (sem) forced expiratory flow was significantly below average (z score = 0) (p < .001) at 6 mos and 12 mos: -1.1 (0.1) and -1.2 (0.1), respectively. At 12 mos, infants with diaphragmatic hernia had a functional residual capacity significantly above normal: mean (sem) z score = 1.2 (0.5).
CONCLUSIONS: : Infants treated with extracorporeal membrane oxygenation have normal lung volumes and stable forced expiratory flows within normal range, although below average, within the first year of life. There is reason to believe, therefore, that extracorporeal membrane oxygenation either ameliorates the harmful effects of mechanical ventilation or somehow preserves lung function in the very ill neonate.
Ward Hofhuis; Manon N Hanekamp; Hanneke Ijsselstijn; Eveline M Nieuwhof; Wim C J Hop; Dick Tibboel; Johan C de Jongste; Peter J F M Merkus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  12     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-06-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
From the Department of Pediatrics (WH, EMN, JCdJ, PJFMM), Division of Pediatric Respiratory Medicine, Department of Pediatric Surgery (MNH, HI, DT), Department of Biostatistics (WCJH), Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
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