Document Detail

Prospective identification of patients with amyloid heart disease by two-dimensional echocardiography.
MedLine Citation:
PMID:  6744547     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine whether changes in myocardial wall echogenicity that suggest amyloid disease could be prospectively identified by a qualitative analysis of two-dimensional echocardiographic images. Two thousand seventy-eight consecutive echocardiograms obtained over a 14 month period were prospectively analyzed. The myocardial walls of 30 patients showed multiple, discrete, small highly refractive echoes; amyloid disease was not known or suspected in any of them. It was recommended that all 30 patients undergo gingival biopsy to confirm the diagnosis and biopsy was performed in 15 patients. The recommendation for biopsy was made only on the basis of two-dimensional echocardiographic images and was independent of findings regarding thickness of the walls or the dimensions of the cardiac chambers. Results of biopsy were positive in 11 patients and negative in four. We conclude that qualitative evaluation of two-dimensional echocardiographic images can identify changes in myocardial wall echogenicity that correlate with a result of gingival biopsy positive for amyloidosis. In patients who have a typical myocardial texture by two-dimensional echocardiography and a positive gingival biopsy result, cardiac amyloidosis should be strongly suspected.
G L Nicolosi; D Pavan; C Lestuzzi; C Burelli; F Zardo; D Zanuttini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  70     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-09-19     Completed Date:  1984-09-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  432-7     Citation Subset:  AIM; IM    
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MeSH Terms
Amyloidosis / diagnosis*,  pathology
Cardiomyopathies / diagnosis*
Echocardiography / methods*
Gingiva / pathology
Gingival Diseases / pathology
Middle Aged
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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