Document Detail

Prospective function of placental leptin at maternal-fetal interface.
MedLine Citation:
PMID:  11945077     Owner:  NLM     Status:  MEDLINE    
Leptin is an endocrine and a growth factor which is important for regulation of body fat, feeding, and energy homeostasis. The anti-obesity function of leptin has been recently extended to reproduction, puberty and pregnancy as an endocrine signal to the hypothalamus. Leptin controls the functional integrity of the feto-placental unit thereby maintaining pregnancy by virtue of its immunomodulatory property via T lymphocytes or other proto-oncogenes. Dysregulation of autocrine/paracrine function of leptin at feto-placento-maternal interface may be implicated in the pathogenesis of recurrent miscarriage gestational diabetes, pre-eclampsia and intra-uterine fetal growth retardation including disturbance of fetal bone turnover. This review will focus on the role of leptin in normal and abnormal pregnancy and fetal growth.
R Bajoria; S R Sooranna; B S Ward; R Chatterjee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Placenta     Volume:  23     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2002 Feb-Mar
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-08-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-15     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary's Hospital, Whitworth Park, Manchester M13 0JH, UK.
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MeSH Terms
Carrier Proteins / metabolism
Diabetes, Gestational / etiology,  metabolism
Fetal Growth Retardation / etiology,  metabolism
Leptin / physiology*
Maternal-Fetal Exchange / physiology*
Placenta / physiology*
Pre-Eclampsia / etiology,  metabolism
Receptors, Cell Surface*
Receptors, Leptin
Signal Transduction
Reg. No./Substance:
0/Carrier Proteins; 0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/leptin receptor, human

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