Document Detail

Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome.
MedLine Citation:
PMID:  18829623     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine tolerance rates to cow's milk and soy and to suggest guidelines for follow-up oral food challenges (FU-OFCs) in infantile food protein-induced enterocolitis syndrome (FPIES). METHODS: The authors analysed the data of 23 patients with infantile FPIES who underwent two or more FU-OFCs and were followed up until over 2 years of age. The first FU-OFCs were performed at 6 months of age, and patients were randomly allocated to cow's milk (n = 11) or soy (n = 12) challenge starting groups. Second and third FU-OFCs were performed at 2-month intervals in a crossed and switched-over manner. RESULTS: Tolerance rates to cow's milk and soy were 27.3% and 75.0% at 6 months of age, 41.7% and 90.9% at 8 months and 63.6% and 91.7% at 10 months, respectively. Patients outgrew cow's milk and soy intolerance at age 20 and 14 months. CONCLUSIONS: In infantile FPIES, the first FU-OFC should be performed with soy at 6-8 months of age and cow's milk FU-OFC should be conducted at over 12 months of age. Infants with FPIES were observed to outgrow food sensitivities during the first 2 years of life.
J-B Hwang; S M Sohn; A S Kim
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-10-01
Journal Detail:
Title:  Archives of disease in childhood     Volume:  94     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-22     Completed Date:  2009-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  425-8     Citation Subset:  AIM; IM    
Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.
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MeSH Terms
Administration, Oral
Enterocolitis / etiology*,  immunology
Follow-Up Studies
Immunoglobulin E / immunology
Milk Proteins / adverse effects*,  immunology
Practice Guidelines as Topic
Prospective Studies
Soybean Proteins / adverse effects*,  immunology
Time Factors
Reg. No./Substance:
0/Milk Proteins; 0/Soybean Proteins; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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