Document Detail

Prospective evaluation of tissue plasminogen activator in 11 cats with arterial thromboembolism.
MedLine Citation:
PMID:  19740689     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the clinical response and side effects of tissue plasminogen activator (tPA) for the treatment of feline arterial thromboembolism (ATE). Previous reports of conservative and thrombolytic therapy were used to provide a historical control group of cats with ATE. The study was terminated due to a high frequency of adverse outcomes. tPA was administered to 11 cats with clinical signs of ATE for a median duration of 4.0 h (range 2-12h) prior to treatment. Pulses were restored in 40% of limbs within 4h and 53% within 24h. Motor function was restored to 33% of limbs within 24h. Adverse effects were seen in 11/11 cats following administration of tPA including azotemia (n=5), neurological signs (n=5), cardiac arrhythmias (n=5), hyperkalemia (n=4), acidosis (n=2) and sudden death in one cat. Ultimately, three cats (27%) were discharged alive from the hospital. While signs compatible with thrombolysis were noted in many cats following tPA administration, a high rate of side effects and low rate of hospital discharge were noted in this study.
Kristin M Welch; Elizabeth A Rozanski; Lisa M Freeman; John E Rush
Related Documents :
6697129 - Prediction of amputation wound healing: the role of transcutaneous po2 assessment.
25150239 - Rectal ulcers induced by systemic lupus erythematosus.
8792989 - Tcpo2 as an accurate predictor of therapy in limb salvage.
16894799 - Effects of lower limb intensive mass practice in poststroke patients: single-subject ex...
3484519 - Spinal cord stimulation in peripheral arterial disease. a cooperative study.
8875999 - Clinical rehabilitation of the amputee: a retrospective study.
23389099 - Radiofrequency ablation of drug-refractory arrhythmias in small children younger than 1...
18317489 - Outcomes of lower urinary and bowel function in meningomyelocele patients with augmenta...
25289079 - Rapid response to systemic bevacizumab therapy in recurrent respiratory papillomatosis.
Publication Detail:
Type:  Journal Article     Date:  2009-09-09
Journal Detail:
Title:  Journal of feline medicine and surgery     Volume:  12     ISSN:  1532-2750     ISO Abbreviation:  J. Feline Med. Surg.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-11     Revised Date:  2011-09-22    
Medline Journal Info:
Nlm Unique ID:  100897329     Medline TA:  J Feline Med Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  122-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 ESFM and AAFP. Published by Elsevier Ltd. All rights reserved.
Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arrhythmias, Cardiac / chemically induced,  veterinary
Azotemia / chemically induced,  veterinary
Cat Diseases / chemically induced*,  drug therapy*
Fibrinolytic Agents / adverse effects,  therapeutic use
Nervous System Diseases / chemically induced,  veterinary
Prospective Studies
Thromboembolism / drug therapy,  veterinary*
Tissue Plasminogen Activator / adverse effects*,  therapeutic use*
Treatment Failure
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Successful surgical treatment of a prostatic biphasic tumour (sarcomatoid carcinoma) in a cat.
Next Document:  Descriptive study of the type of patient cared for in a link-nursing program.