Document Detail


Prospective evaluation of tissue plasminogen activator in 11 cats with arterial thromboembolism.
MedLine Citation:
PMID:  19740689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate the clinical response and side effects of tissue plasminogen activator (tPA) for the treatment of feline arterial thromboembolism (ATE). Previous reports of conservative and thrombolytic therapy were used to provide a historical control group of cats with ATE. The study was terminated due to a high frequency of adverse outcomes. tPA was administered to 11 cats with clinical signs of ATE for a median duration of 4.0 h (range 2-12h) prior to treatment. Pulses were restored in 40% of limbs within 4h and 53% within 24h. Motor function was restored to 33% of limbs within 24h. Adverse effects were seen in 11/11 cats following administration of tPA including azotemia (n=5), neurological signs (n=5), cardiac arrhythmias (n=5), hyperkalemia (n=4), acidosis (n=2) and sudden death in one cat. Ultimately, three cats (27%) were discharged alive from the hospital. While signs compatible with thrombolysis were noted in many cats following tPA administration, a high rate of side effects and low rate of hospital discharge were noted in this study.
Authors:
Kristin M Welch; Elizabeth A Rozanski; Lisa M Freeman; John E Rush
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Publication Detail:
Type:  Journal Article     Date:  2009-09-09
Journal Detail:
Title:  Journal of feline medicine and surgery     Volume:  12     ISSN:  1532-2750     ISO Abbreviation:  J. Feline Med. Surg.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-11     Revised Date:  2011-09-22    
Medline Journal Info:
Nlm Unique ID:  100897329     Medline TA:  J Feline Med Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  122-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 ESFM and AAFP. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA, USA. kristin.welch@tufts.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / chemically induced,  veterinary
Azotemia / chemically induced,  veterinary
Cat Diseases / chemically induced*,  drug therapy*
Cats
Female
Fibrinolytic Agents / adverse effects,  therapeutic use
Male
Nervous System Diseases / chemically induced,  veterinary
Prospective Studies
Thromboembolism / drug therapy,  veterinary*
Tissue Plasminogen Activator / adverse effects*,  therapeutic use*
Treatment Failure
Treatment Outcome
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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