Document Detail

Prospective evaluation of posttransfusion hepatitis.
MedLine Citation:
PMID:  1850568     Owner:  NLM     Status:  MEDLINE    
The incidence of posttransfusion hepatitis (PTH) was determined prospectively at our institution. An active surveillance program of transfused surgical patients was set up; alanine aminotransferase (ALT) levels were determined before transfusion and at monthly intervals for 6 months after transfusion. Patients with confirmed ALT values greater than 2.5 times the upper reference values were referred to the out-patient clinics for diagnosis. Of 4051 surgical patients who underwent transfusion between January 1986 and December 1989, 2459 (60.7%) were enrolled in the surveillance program, and 1018 (25.1%) completed the follow-up; 238 patients received autologous blood only and were used as controls. No PTH was observed in the control patients, and the incidence of the disease in patients receiving homologous blood was 10.97 percent in 1986, 6.58 percent in 1987, 5.55 percent in 1988, and 4.29 percent in 1989; the decreasing trend is significant (p = 0.018).
G Sirchia; A M Giovanetti; A Parravicini; A Bellobuono; F Mozzi; M N Pizzi; D Almini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  31     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-30     Completed Date:  1991-05-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  IM    
Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore, Milan, Italy.
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MeSH Terms
Alanine Transaminase / blood
Blood Transfusion / adverse effects*
Cytomegalovirus Infections
Hepatitis C / epidemiology,  transmission
Hepatitis, Viral, Human / epidemiology*,  microbiology,  transmission
Herpesviridae Infections
Herpesvirus 4, Human
Prospective Studies
Surgical Procedures, Operative
Reg. No./Substance:
EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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