Document Detail

Prospective evaluation of perinatal risk factors for cerebral palsy and delayed development in high risk infants.
MedLine Citation:
PMID:  10487140     Owner:  NLM     Status:  MEDLINE    
Prematurity, intrauterine infection and perinatal brain injury have been reported to be significant risk factors of cerebral palsy (CP). We examined the perinatal predictors of cerebral palsy and delayed development (DD) in 184 high risk infants. Thirty-five infants were diagnosed as cerebral palsy and delayed development at 12 months corrected age. Antenatal, intrapartum, and neonatal factors were prospectively evaluated in 2 groups of high risk infants compared with controls; Group A (n = 79), infants weighing less than 2,000 g; Group B (n = 43), infants weighing 2,000 g or more. In univariate analysis, there were no significant antenatal and intrapartum factors associated with cerebral palsy and delayed development in either group. We found that significant postnatal risk factors of CP in group A included sepsis (p = 0.008), BPD (bronchopulmonary dysplasia) (p = 0.028), IVH (intraventricular hemorrhage) (p = 0.042), ventriculomegaly (VM) (p = 0.001) and a longer duration of mechanical ventilation (p = 0.001); while in group B, sepsis (p = 0.047) and neonatal seizure (p = 0.027) were significant risk factors. In multivariate analysis, sepsis in group B was a moderate risk factor of CP (OR (odds ratio) 1.47; 95% CI (confidence interval) 1.02-2.13). In conclusion, neonatal sepsis may contribute to the development of cerebral palsy and delayed development. We suggest that high risk infants who have sepsis should be carefully followed for cerebral palsy and delayed development. The prevention of cerebral palsy may be feasible by decreasing neonatal risk factors such as sepsis during the neonatal period.
J N Kim; R Namgung; W Chang; C H Oh; J C Shin; E S Park; C I Park; M S Park; K I Park; C Lee; D G Han
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Yonsei medical journal     Volume:  40     ISSN:  0513-5796     ISO Abbreviation:  Yonsei Med. J.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-28     Completed Date:  1999-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414003     Medline TA:  Yonsei Med J     Country:  KOREA (SOUTH)    
Other Details:
Languages:  eng     Pagination:  363-70     Citation Subset:  IM    
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
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MeSH Terms
Cerebral Palsy / etiology*
Child Development*
Developmental Disabilities / etiology*
Infant, Newborn
Infant, Newborn, Diseases*
Prospective Studies
Risk Factors

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