Document Detail

Prospective evaluation of patients with bowel wall thickening.
MedLine Citation:
PMID:  7801959     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Thickening of the gastrointestinal bowel wall is commonly identified by abdominal computed tomographic (CT) imaging. The objective of this study was to prospectively determine the prevalence of substantial pathological abnormalities in patients with bowel wall thickening by computed tomography. METHODS: Consecutive patients with bowel wall (gastric, duodenal, or colonic) thickening prospectively identified by CT underwent endoscopy of the portion of the bowel that was identified as abnormal. RESULTS: Over an 18-month period, 50 patients with bowel wall thickening underwent directed endoscopic examination. Fifteen patients of the cohort were HIV-positive. The likelihood of detecting an abnormality by endoscopy in the entire population was 67%. Furthermore, for patients with endoscopic abnormalities, 42% had a specific histological diagnosis made by biopsy taken during the endoscopy. Clinical parameters did not predict abnormal endoscopic findings for patients with an abnormal computed tomographic exam. Although the rate of endoscopic abnormalities did not significantly differ between HIV-positive and HIV-negative patients, specific histological findings were more common among the former patients. CONCLUSIONS: In patients with bowel wall thickening identified by CT, endoscopy demonstrates abnormalities in the majority of cases. Endoscopy is useful in this patient population because it yields accurate identification of abnormalities and also permits direct biopsy. Among patients with bowel wall thickening identified by CT, in whom a specific diagnosis is not evident, endoscopy of the relevant portion of the bowel should be strongly considered.
D C Rockey; R A Halvorsen; J L Higgins; J P Cello
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  90     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-01-26     Completed Date:  1995-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM; X    
Department of Medicine, San Francisco General Hospital, University of California.
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MeSH Terms
Colon / pathology
Diagnosis, Differential
Digestive System / pathology*,  radiography,  virology
Duodenum / pathology
Endoscopy, Gastrointestinal
Gastrointestinal Diseases / diagnosis*
HIV Seropositivity / pathology
Hyperplasia / pathology
Hypertrophy / pathology
Prospective Studies
Stomach / pathology
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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