Document Detail

Prospective evaluation of non-pharmacological treatment in vasovagal syncope.
MedLine Citation:
PMID:  20047924     Owner:  NLM     Status:  MEDLINE    
AIMS: Initial treatment of vasovagal syncope (VVS) consists of assuring an adequate fluid and salt intake, regular exercise and application of physical counterpressure manoeuvres. We examined the effects of this non-pharmacological treatment in patients with frequent recurrences. METHODS AND RESULTS: One hundred patients with > or =3 episodes of VVS in the 2 years prior to the start of the study openly received non-pharmacological treatment. We evaluated this treatment both with respect to syncopal recurrences, factors associated with recurrence, and quality of life (QoL). The median number of syncopal recurrences was lower in the first year of non-pharmacological treatment compared with the last year before treatment (median 0 vs. 3; P < 0.001), but 49% of patients experienced at least one recurrence. In multivariable analysis, a higher syncope burden prior to inclusion was significantly associated with syncopal recurrence. Disease-specific QoL improved over time, with larger improvements for patients with more reduction in syncope burden. CONCLUSION: In patients with frequent recurrences of VVS, non-pharmacological treatment has a beneficial effect on both syncopal recurrence and QoL, but nearly half of these patients still experience episodes of syncope.
Jacobus J C M Romme; Johannes B Reitsma; Ingeborg K Go-Sch?n; Mark P M Harms; Jaap H Ruiter; Jan S K Luitse; Jacques W M Lenders; Wouter Wieling; Nynke van Dijk
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-03
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  12     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  567-73     Citation Subset:  IM    
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, J1b-214, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.
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MeSH Terms
Biofeedback, Psychology / methods*
Blood Pressure
Disease-Free Survival
Life Style*
Middle Aged
Multivariate Analysis
Prospective Studies
Quality of Life
Sodium, Dietary
Syncope, Vasovagal / physiopathology,  therapy*
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Sodium, Dietary
Comment In:
Europace. 2010 Apr;12(4):466-7   [PMID:  20106794 ]

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