| Prospective evaluation of hybrid 18F-fluorodeoxyglucose positron emission tomography/computed tomography in staging clinically node-negative patients with penile carcinoma. | |
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MedLine Citation:
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PMID: 19281465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To prospectively evaluate the performance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to detect occult metastasis in patients with clinically node-negative (cN0) penile carcinoma, as there is little information on the use of (18)F-FDG-PET/CT in penile carcinoma. PATIENTS AND METHODS: In 24 patients, scheduled to undergo dynamic sentinel-node biopsy, hybrid PET/CT was used before surgery to assess the nodal status of the cN0-groins. Six of the 24 patients were unilaterally cN0. Thus, 42 cN0-groins were evaluated for occult metastasis using PET/CT. All scans were assessed by two experienced nuclear physicians. The histopathological tumour status of the removed sentinel node was used as the standard of care to evaluate the PET/CT-results. RESULTS: Histopathology was tumour-positive in five of the 42 (12%) evaluated cN0-groins, two of which contained only micrometastases (<2 mm). One of the five tumour-positive cN0-groins was correctly predicted on the PET/CT-images. All false-negative PET/CT scans contained metastasis of <or=10 mm. Of the remaining 37 tumour-negative groins, 34 were correctly predicted with PET/CT (specificity 92%). CONCLUSION: The role of PET/CT in evaluating the groins of patients with cN0 penile cancer appears to be limited, due to its low sensitivity. In this series, only one of the five tumour-positive groins was identified. Surgical staging methods remain necessary at present. |
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Authors:
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Joost A P Leijte; Niels M Graafland; Renato A Valdés Olmos; Hester H van Boven; Cornelis A Hoefnagel; Simon Horenblas |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2009-03-05 |
Journal Detail:
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Title: BJU international Volume: 104 ISSN: 1464-410X ISO Abbreviation: BJU Int. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-19 Completed Date: 2009-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886721 Medline TA: BJU Int Country: England |
Other Details:
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Languages: eng Pagination: 640-4 Citation Subset: IM |
Affiliation:
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Department of Urology, The Netherlands Cancer Institute--Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Epidemiologic Methods Fluorodeoxyglucose F18 / diagnostic use* Groin Humans Immunohistochemistry Lymph Nodes* / pathology, radiography, radionuclide imaging Lymphatic Metastasis / radiography, radionuclide imaging Male Middle Aged Neoplasm Staging Penile Neoplasms* / pathology, radiography, radionuclide imaging Positron-Emission Tomography / methods*, standards Radiopharmaceuticals / diagnostic use* Tomography, X-Ray Computed / methods*, standards |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
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