Document Detail

Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients.
MedLine Citation:
PMID:  19694721     Owner:  NLM     Status:  MEDLINE    
Low steady state haemoglobin oxygen saturation in patients with sickle cell anaemia has been associated with the degree of anaemia and haemolysis. How much pulmonary dysfunction contributes to low saturation is not clear. In a prospective study of children and adolescents with sickle cell disease aged 3-20 years at steady state and matched controls, 52% of 391 patients versus 24% of 63 controls had steady state oxygen saturation <99% (P < 0.0001), 9% of patients versus no controls had saturation <95% (P = 0.008) and 8% of patients versus no controls had exercise-induced reduction in saturation > or =3%. Decreasing haemoglobin concentration (P < or = 0.001) and increasing haemolysis (P < or = 0.003) but not pulmonary function tests were independent predictors of both lower steady-state saturation and exercise-induced reduction in saturation. Neither history of stroke nor history of acute chest syndrome was significantly associated with lower steady-state oxygen saturation or exercise-induced reduction in saturation. Tricuspid regurgitation velocity was higher in patients with lower steady state haemoglobin oxygen saturation (P = 0.003) and with greater decline in oxygen saturation during the six-minute walk (P = 0.022). In conclusion, lower haemoglobin oxygen saturation is independently associated with increasing degrees of anaemia and haemolysis but not pulmonary function abnormalities among children and adolescents with sickle cell disease.
Andrew Campbell; Caterina P Minniti; Mehdi Nouraie; Manuel Arteta; Sohail Rana; Onyinye Onyekwere; Craig Sable; Gregory Ensing; Niti Dham; Lori Luchtman-Jones; Gregory J Kato; Mark T Gladwin; Oswaldo L Castro; Victor R Gordeuk
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2009-08-19
Journal Detail:
Title:  British journal of haematology     Volume:  147     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-02-23     Revised Date:  2011-10-19    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  352-9     Citation Subset:  IM    
University of Michigan, Ann Arbor, MI, USA.
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MeSH Terms
Anemia, Sickle Cell / blood*,  physiopathology
Child, Preschool
Exercise / physiology*
Exercise Test / methods
Hemoglobins / metabolism*
Logistic Models
Oxygen / blood*
Prospective Studies
Respiratory Function Tests / methods
Respiratory Physiological Phenomena
Young Adult
Grant Support
1 R01 HL079912-02/HL/NHLBI NIH HHS; 2 R25 HL003679-08/HL/NHLBI NIH HHS; 2MOI RR10284-10/RR/NCRR NIH HHS; Z01 CL008098-01/CL/CLC NIH HHS; Z01 CL008098-02/CL/CLC NIH HHS; ZIA HL006016-01/HL/NHLBI NIH HHS; ZIA HL006016-02/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

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