| Prospective evaluation of abnormal liver function tests in pregnancy. | |
| | |
MedLine Citation:
|
PMID: 16737048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Abnormalities in liver function tests (LFT) during pregnancy are a commonly encountered problem often associated with serious consequences especially when it occurs in the third trimester. The spectrum of abnormal liver functions in pregnancy can be fairly wide and diagnostic work up often challenging. There is insufficient prospective data on the spectrum and outcome of liver disease in pregnant population from south India. This study was performed to assess the causes of deranged liver function in the pregnant population and also to prospectively determine the outcome of liver dysfunction in pregnancy. All abnormal LFT results observed in serum samples from pregnant patients attending the obstetric unit of our hospital from January 2003 to January 2005 were evaluated and prospectively followed throughout pregnancy. Laboratory investigations included coagulation profile, renal function tests, serology for viral markers (HBsAg, anti-HCV, IgM anti-HEV and IgM anti-HAV) and other relevant biochemical tests. In those with liver dysfunction in the third trimester the maternal and perinatal outcome was evaluated. A total of 125 patients were identified with abnormalities in LFT results during this period. The majority of causes were related to pregnancy specific conditions (57.6%). Most episodes of abnormal LFT occurred in the third trimester (59.2%). Hyperemesis gravidarum (55.8%) and viral hepatitis (47%) were the most common causes of abnormal LFT in the first and second trimesters respectively. HELLP (28.3%) and AFLP (14.8%) were the most common causes of abnormal LFT in the third trimester. There were no mAternal deaths due to liver dysfunction in the first or second trimester. Liver dysfunction in the third trimester (74 patients) was associated with serious consequences. DIC was the most common complication (20.2%). The overall and perinatal mortality was 20.2% and 24.6% respectively. AFLP and HELLP syndromes were associated with poor maternal and fetal outcome. We conclude that liver dysfunctions were directly related to pregnancy in the majority of patients especially in the third namely trimester. Incidence of the most serious conditions AFLP and HELLP syndromes is much greater than what has been reported and is often associated with a high maternal mortality and poor perinatal outcome. |
| | |
Authors:
|
K Harish; R Nitha; R Harikumar; K Sunil Kumar; Thomas Varghese; N S Sreedevi; K Bushrath; K Sandesh; J Tony |
Related Documents
:
|
22535728 - Prenatal sonography in hydranencephaly: findings during the early stages of disease. 22157338 - Understanding hydatidiform mole. 18990428 - Human udp-glucuronosyltransferase isoforms involved in bisphenol a glucuronidation. 12170538 - Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and ... 16145648 - Growth discrepancy in twins in the first trimester of pregnancy. 16251738 - A baboon model for simulating pregnancy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Tropical gastroenterology : official journal of the Digestive Diseases Foundation Volume: 26 ISSN: 0250-636X ISO Abbreviation: Trop Gastroenterol Publication Date: 2005 Oct-Dec |
Date Detail:
|
Created Date: 2006-06-01 Completed Date: 2006-06-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8107122 Medline TA: Trop Gastroenterol Country: India |
Other Details:
|
Languages: eng Pagination: 188-93 Citation Subset: IM |
Affiliation:
|
Calicut Medical College, Kozhikode 673 008, Kerala. dr_harishk@yahoo.co.in |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Humans India / epidemiology Liver Diseases / diagnosis, epidemiology* Liver Function Tests Pregnancy Pregnancy Complications / diagnosis, epidemiology* Pregnancy Outcome Pregnancy Trimesters Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characteristics of dual infection of hepatitis B and C viruses among patients with chronic liver dis...
Next Document: Presentation and management outcome of inflammatory bowel disease in Sudan.