| Prospective echocardiographic evaluation of atrioventricular conduction in fetuses with maternal Sjögren's antibodies. | |
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MedLine Citation:
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PMID: 15467582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Fetal complete atrioventricular block (AVB) occurs in 2-5% of Sjögren's antibodies (SSA/SSB)-positive pregnancies with substantial morbidity and mortality. We evaluated the incidence of 1 degrees and 2 degrees AVB by measuring Doppler-derived mechanical PR intervals. STUDY DESIGN: We compared mechanical PR intervals of fetuses of SSA/SSB positive mothers referred to a single cardiology center between 1997 and 2003 with control fetuses and fetuses with 1 degrees or 2 degrees AVB confirmed by magnetocardiography or postnatal electrocardiogram. RESULTS: One hundred thirty-nine fetal echocardiograms performed on 59 SSA/SSB-positive pregnant women at 24.3 +/- 5.0 weeks gestation were compared with 150 controls. Mechanical PR intervals of the study group (120.5 +/- 9.8 milliseconds) and controls (120.6 +/- 8.7 milliseconds) were the same but differed significantly from fetuses with 1 degrees and 2 degrees AVB (191.5 +/- 29.6 msec). CONCLUSION: The incidence of 1 degrees and degrees 2 fetal AVB in SSA/SSB-positive pregnancies is low and can be identified by abnormal mechanical PR interval. |
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Authors:
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Andrew H Van Bergen; Bettina F Cuneo; Nancy Davis |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 191 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-10-06 Completed Date: 2004-11-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1014-8 Citation Subset: AIM; IM |
Affiliation:
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The Heart Institute for Children, Hope Children's Hospital, Oak Lawn, Ill 60453, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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blood* Electrocardiography Female Fetal Blood / immunology* Fetal Diseases / epidemiology, ultrasonography Gestational Age Heart Block / epidemiology, ultrasonography* Heart Rate, Fetal Humans Pregnancy Pregnancy Complications / immunology* Prospective Studies Sjogren's Syndrome / immunology* Ultrasonography, Prenatal* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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