Document Detail


Prospective echocardiographic evaluation of atrioventricular conduction in fetuses with maternal Sjögren's antibodies.
MedLine Citation:
PMID:  15467582     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Fetal complete atrioventricular block (AVB) occurs in 2-5% of Sjögren's antibodies (SSA/SSB)-positive pregnancies with substantial morbidity and mortality. We evaluated the incidence of 1 degrees and 2 degrees AVB by measuring Doppler-derived mechanical PR intervals. STUDY DESIGN: We compared mechanical PR intervals of fetuses of SSA/SSB positive mothers referred to a single cardiology center between 1997 and 2003 with control fetuses and fetuses with 1 degrees or 2 degrees AVB confirmed by magnetocardiography or postnatal electrocardiogram. RESULTS: One hundred thirty-nine fetal echocardiograms performed on 59 SSA/SSB-positive pregnant women at 24.3 +/- 5.0 weeks gestation were compared with 150 controls. Mechanical PR intervals of the study group (120.5 +/- 9.8 milliseconds) and controls (120.6 +/- 8.7 milliseconds) were the same but differed significantly from fetuses with 1 degrees and 2 degrees AVB (191.5 +/- 29.6 msec). CONCLUSION: The incidence of 1 degrees and degrees 2 fetal AVB in SSA/SSB-positive pregnancies is low and can be identified by abnormal mechanical PR interval.
Authors:
Andrew H Van Bergen; Bettina F Cuneo; Nancy Davis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-11-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1014-8     Citation Subset:  AIM; IM    
Affiliation:
The Heart Institute for Children, Hope Children's Hospital, Oak Lawn, Ill 60453, USA.
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MeSH Terms
Descriptor/Qualifier:
Antibodies / blood*
Electrocardiography
Female
Fetal Blood / immunology*
Fetal Diseases / epidemiology,  ultrasonography
Gestational Age
Heart Block / epidemiology,  ultrasonography*
Heart Rate, Fetal
Humans
Pregnancy
Pregnancy Complications / immunology*
Prospective Studies
Sjogren's Syndrome / immunology*
Ultrasonography, Prenatal*
Chemical
Reg. No./Substance:
0/Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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