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Prospective, double-blinded, randomised controlled trial assessing the effect of an Octenidine-based hydrogel on bacterial colonisation and epithelialization of skin graft wounds in burn patients.
MedLine Citation:
PMID:  23071904     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Moist wound treatment improves healing of skin graft donor site wounds. Microbial colonised wounds represent an increased risk of wound infection; while antimicrobially active, topical antiseptics may impair epithelialization.
OBJECTIVES: The aim of this prospective randomised controlled clinical trial was to examine the influence of an Octenidine-dihydrochloride (OCT) hydrogel on bacterial colonisation and epithelialization of skin graft donor sites.
METHODS: The study was designed as a randomised, double-blinded, controlled clinical trial. Skin graft donor sites from a total of 61 patients were covered either with 0.05% OCT (n=31) or an OCT-free placebo wound hydrogel (n=30). Potential interaction with wound healing was assessed by measuring the time until 100% re-epithelialization. In addition, microbial wound colonisation was quantitatively determined in all skin graft donor sites.
RESULTS: There was no statistically significant difference in the time for complete epithelialization of skin graft donor sites in the OCT and the placebo group (7.3±0.2 vs. 6.9±0.2 days; p=0.236). Microbial wound colonisation was significantly lower in the OCT group than in the placebo group (p=0.014).
CONCLUSIONS: The OCT-based hydrogel showed no delay in wound epithelialization and demonstrated a significantly lower bacterial colonisation of skin graft donor site wounds.
Eisenbeiß W; Siemers F; Amtsberg G; Hinz P; Hartmann B; Kohlmann T; Ekkernkamp A; Albrecht U; Assadian O; Kramer A
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Publication Detail:
Type:  Journal Article     Date:  2012-09-15
Journal Detail:
Title:  International journal of burns and trauma     Volume:  2     ISSN:  2160-2026     ISO Abbreviation:  Int J Burns Trauma     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-16     Completed Date:  2012-10-17     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101581623     Medline TA:  Int J Burns Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-9     Citation Subset:  -    
Department of Surgery and Plastic Surgery, University Medical Centre Schleswig-Holstein, Lübeck Germany.
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