| Prospective, double-blinded, randomised controlled trial assessing the effect of an Octenidine-based hydrogel on bacterial colonisation and epithelialization of skin graft wounds in burn patients. | |
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MedLine Citation:
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PMID: 23071904 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Moist wound treatment improves healing of skin graft donor site wounds. Microbial colonised wounds represent an increased risk of wound infection; while antimicrobially active, topical antiseptics may impair epithelialization. OBJECTIVES: The aim of this prospective randomised controlled clinical trial was to examine the influence of an Octenidine-dihydrochloride (OCT) hydrogel on bacterial colonisation and epithelialization of skin graft donor sites. METHODS: The study was designed as a randomised, double-blinded, controlled clinical trial. Skin graft donor sites from a total of 61 patients were covered either with 0.05% OCT (n=31) or an OCT-free placebo wound hydrogel (n=30). Potential interaction with wound healing was assessed by measuring the time until 100% re-epithelialization. In addition, microbial wound colonisation was quantitatively determined in all skin graft donor sites. RESULTS: There was no statistically significant difference in the time for complete epithelialization of skin graft donor sites in the OCT and the placebo group (7.3±0.2 vs. 6.9±0.2 days; p=0.236). Microbial wound colonisation was significantly lower in the OCT group than in the placebo group (p=0.014). CONCLUSIONS: The OCT-based hydrogel showed no delay in wound epithelialization and demonstrated a significantly lower bacterial colonisation of skin graft donor site wounds. |
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Authors:
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Eisenbeiß W; Siemers F; Amtsberg G; Hinz P; Hartmann B; Kohlmann T; Ekkernkamp A; Albrecht U; Assadian O; Kramer A |
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Publication Detail:
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Type: Journal Article Date: 2012-09-15 |
Journal Detail:
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Title: International journal of burns and trauma Volume: 2 ISSN: 2160-2026 ISO Abbreviation: Int J Burns Trauma Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-16 Completed Date: 2012-10-17 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 101581623 Medline TA: Int J Burns Trauma Country: United States |
Other Details:
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Languages: eng Pagination: 71-9 Citation Subset: - |
Affiliation:
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Department of Surgery and Plastic Surgery, University Medical Centre Schleswig-Holstein, Lübeck Germany. |
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