Document Detail

Prospective controlled vagotomy trial for duodenal ulcer. Results after 11-15 years.
MedLine Citation:
PMID:  2642689     Owner:  NLM     Status:  MEDLINE    
A prospective, randomized, controlled trial was conducted to compare truncal vagotomy and drainage (TV), selective vagotomy and drainage (SV) and parietal cell vagotomy (PCV) as elective treatment for duodenal ulcer. Between 11 and 15 years after operation, 248 patients were available for study of the recurrent ulceration rate by a life table method, and 197 patients could be studied with regard to postvagotomy symptoms. The recurrent ulcer rates were 28.5% for TV, 37.4% for SV, and 39.3% for PCV. These differences were not statistically significant. The incidence of severe postvagotomy symptoms was as follows: dyspepsia, 18.4% for TV, 20.5% for SV, 8.6% for PCV; dumping, 5.9% for TV, 19.6% for SV, 2.2% for PCV; diarrhea, 9.8% for TV, 11.8% for SV, 4.4% for PCV. The incidence of severe dumping was significantly less frequent among the PCV patients than the SV group. The differences did not reach statistical significance in any of the other groups. There was no significant difference in the Visick gradings among the three groups either before or after treatment of the failures. About two thirds of the patients in each group were finally satisfied with their operation, often after second operations or prolonged medical treatment. It is concluded that none of the three forms of vagotomy can be recommended as the standard operative treatment of duodenal ulceration.
J Hoffmann; H E Jensen; J Christiansen; A Olesen; F B Loud; O Hauch
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of surgery     Volume:  209     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  40-5     Citation Subset:  AIM; IM    
Department of Surgery I, Kommunehospitalet, Copenhagen, Denmark.
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MeSH Terms
Clinical Trials as Topic
Duodenal Ulcer / classification,  surgery*
Evaluation Studies as Topic
Follow-Up Studies
Prospective Studies
Random Allocation
Time Factors
Vagotomy / adverse effects,  methods*
Vagotomy, Proximal Gastric
Vagotomy, Truncal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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