Document Detail

Prospective controlled randomized trial of prophylactic antiarrhythmic therapy in postmyocardial infarction patients with asymptomatic ventricular arrhythmias--study design and initial results.
MedLine Citation:
PMID:  3078156     Owner:  NLM     Status:  MEDLINE    
In order to assess the effect of prophylactic antiarrhythmic therapy in asymptomatic patients with persistent complex ventricular ectopic activity after myocardial infarction, a prospective controlled trial was started in 1981 and is still ongoing. Until August 1986, 965 consecutive patients less than or equal to 70 hospitalized for acute myocardial infarction were screened without antiarrhythmic drugs by 24-h ECG before discharge from the hospital. In this group, 238 patients (28%) had ventricular arrhythmias Lown class III-IVb during at least 2 of 24 hours; they were randomly assigned to three treatment groups: (1) individualized antiarrhythmic therapy based on efficacy in multiple 24-h ECGs and drug level determinations (starting with mexiletine or quinidine; n = 79), (2) treatment with low-dose amiodarone (200-400 mg/day after a loading phase; n = 73), and (3) no antiarrhythmic therapy (n = 86). The three groups were comparable regarding age, gender, previous infarction, Q-wave infarction, ejection fraction, as well as incidence and severity of ventricular ectopic activity. Follow-up, including 24-h ECGs, was performed after 3, 6, and 12 months. Based on the results of this study which will be completed by the end of June 1988, it should be possible to estimate the benefit--or harm--of antiarrhythmic drug therapy as well as its cost in postmyocardial infarction patients with asymptomatic ventricular ectopic activity and to decide whether such treatment may improve survival.
M Pfisterer; F Burkart; F Follath; D Burckhardt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical cardiology     Volume:  11     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1990-03-15     Completed Date:  1990-03-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  II41-5     Citation Subset:  IM    
Division of Cardiology, University Hospital, Basel, Switzerland.
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MeSH Terms
Anti-Arrhythmia Agents / adverse effects,  therapeutic use*
Arrhythmias, Cardiac / drug therapy*,  epidemiology,  etiology
Middle Aged
Myocardial Infarction / complications*,  mortality
Prospective Studies
Randomized Controlled Trials as Topic
Research Design
Survival Rate
Switzerland / epidemiology
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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