Document Detail

Prospective controlled evaluation of auditory function in neonates given netilmicin or amikacin.
MedLine Citation:
PMID:  3880819     Owner:  NLM     Status:  MEDLINE    
Longitudinal assessment of intensive care nursery infants given aminoglycoside antibiotics revealed no significant difference in the incidence of hearing impairment when compared with age- and sex-matched controls. Bilateral sensorineural impairment was confirmed in three (2%) infants, one each given netilmicin and amikacin and one untreated control infant. There was a high incidence of transient auditory abnormalities in this intensive care infant population. These findings emphasize the importance of long-term follow-up hearing evaluations in infants who require intensive care management in the neonatal period.
T Finitzo-Hieber; G H McCracken; K C Brown
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  106     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-02-14     Completed Date:  1985-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  AIM; IM    
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MeSH Terms
Amikacin / administration & dosage,  adverse effects*,  therapeutic use
Audiometry, Evoked Response
Bilirubin / blood
Clinical Trials as Topic
Creatinine / blood
Follow-Up Studies
Gentamicins / adverse effects*
Hearing Loss, Sensorineural / chemically induced*,  diagnosis
Infant, Newborn
Infant, Newborn, Diseases / blood,  drug therapy*
Kanamycin / analogs & derivatives*
Longitudinal Studies
Netilmicin / administration & dosage,  adverse effects*,  therapeutic use
Prospective Studies
Reg. No./Substance:
0/Gentamicins; 37517-28-5/Amikacin; 56391-56-1/Netilmicin; 59-01-8/Kanamycin; 60-27-5/Creatinine; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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