| Prospective comparison of 18F-fluorodeoxyglucose positron emission tomography/computed tomography and whole-body magnetic resonance imaging in staging of advanced malignant melanoma. | |
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MedLine Citation:
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PMID: 17224266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of our study was to compare the overall and site-based accuracy and impact on patient management of positron emission tomography/computed tomography (PET/CT) and whole-body (wb) magnetic resonance imaging (MRI) in staging of advanced melanoma. In a prospective blinded study, 64 patients with American Joint Committee on Cancer (AJCC) stage III/IV melanoma underwent 18F-fluorodeoxyglucose PET/CT and wbMRI. In total 420 lesions were evaluated. The overall accuracy of PET/CT was 86.7% compared to 78.8% for wbMRI (P=0.0007). PET/CT was significantly more accurate in N-staging and detecting of skin and subcutaneous metastases, whereas wbMRI was more sensitive in detecting liver, bone and brain metastases. WbMRI was less sensitive but more specific than PET/CT in classifying pulmonary lesions. In 41 patients (64%) whole-body imaging caused changes of treatment. Whole-body staging of patients with advanced melanoma is most accurate by combining wbPET/CT and organ-specific wbMRI including a brain, liver and bone marrow protocol. |
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Authors:
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Christina Pfannenberg; Philip Aschoff; Sandra Schanz; Susanne M Eschmann; Christian Plathow; Thomas K Eigentler; Claus Garbe; Klaus Brechtel; Reinhard Vonthein; Roland Bares; Claus D Claussen; Heinz P Schlemmer |
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Publication Detail:
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Type: Journal Article Date: 2007-01-16 |
Journal Detail:
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Title: European journal of cancer (Oxford, England : 1990) Volume: 43 ISSN: 0959-8049 ISO Abbreviation: Eur. J. Cancer Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005373 Medline TA: Eur J Cancer Country: England |
Other Details:
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Languages: eng Pagination: 557-64 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, Eberhard-Karls-University Tuebingen, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany. christina.pfannenberg@med.uni-tuebingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Fluorodeoxyglucose F18 / diagnostic use* Humans Magnetic Resonance Imaging / methods Male Melanoma / diagnosis*, therapy Middle Aged Neoplasm Staging / methods Positron-Emission Tomography / methods Reference Standards Skin Neoplasms / diagnosis*, therapy Tomography, X-Ray Computed Whole Body Imaging / methods |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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