Document Detail

Prospective comparative trial of moxalactam versus ampicillin or chloramphenicol for treatment of Haemophilus influenzae type b meningitis in children.
MedLine Citation:
PMID:  6368777     Owner:  NLM     Status:  MEDLINE    
In a prospective, randomized study, moxalactam in 44 children was compared with ampicillin or chloramphenicol in 47 children for the treatment of Haemophilus influenzae type b meningitis. Both groups were comparable in terms of clinical and laboratory findings at admission. The hospital course, neurologic sequelae including deafness, and number of deaths were the same for both groups. The incidence of adverse reactions also was the same except that diarrhea and thrombocytosis occurred significantly (P less than or equal to 0.04) more frequently in children given moxalactam. Moxalactam was equivalent to ampicillin or chloramphenicol in the treatment of H. influenzae type b meningitis in children.
S L Kaplan; E O Mason; S K Mason; F I Catlin; R T Lee; M Murphy; R D Feigin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  104     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-02     Completed Date:  1984-05-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-53     Citation Subset:  AIM; IM    
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MeSH Terms
Ampicillin / administration & dosage*,  adverse effects
Blood Cell Count
Child, Preschool
Chloramphenicol / administration & dosage*,  adverse effects
Clinical Trials as Topic
Drug Therapy, Combination
Haemophilus influenzae / drug effects
Hearing Loss, Sensorineural / etiology
Meningitis, Haemophilus / cerebrospinal fluid,  complications,  drug therapy*
Moxalactam / administration & dosage*,  adverse effects
Penicillin Resistance
Prospective Studies
Reg. No./Substance:
56-75-7/Chloramphenicol; 64952-97-2/Moxalactam; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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