Document Detail

Prospective comparative study of cefotetan with piperacillin for prophylaxis against infection in elective colorectal surgery.
MedLine Citation:
PMID:  2342006     Owner:  NLM     Status:  MEDLINE    
This study compared one dose of cefotetan with three doses of piperacillin as prophylaxis against wound infection in 153 patients undergoing elective colorectal surgery. The patients were randomized into two groups: the first received 2 g cefotetan intravenously with induction of anaesthesia (n = 75), and the second received three doses of 2 g piperacillin (n = 78). Wound infection was defined as the presence of an abscess or discharging pus from the wound. In the cefotetan group there were 14 (19%) wound infections and 13 (17%) in the piperacillin group. There were three septic deaths, one in the cefotetan group and two in the piperacillin group. Both groups were comparable with regard to age, sex, nature of pathology and pre- and perioperative risk factors. No significant haematological or biochemical abnormalities were detected. The only adverse reaction was one patient who had an allergic reaction (rash) to piperacillin. These data suggest that single-dose cefotetan is as effective as triple-dose piperacillin in prophylaxis against infection in elective colorectal surgery.
M J Hershman; R I Swift; D T Reilly; W A Logan; J M Sackier; H Gompertz; J Horner; N W Baker; C B Wood
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Royal College of Surgeons of Edinburgh     Volume:  35     ISSN:  0035-8835     ISO Abbreviation:  J R Coll Surg Edinb     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-06-25     Completed Date:  1990-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503110     Medline TA:  J R Coll Surg Edinb     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  IM    
Department of Surgery, Hammersmith Hospital, London, UK.
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MeSH Terms
Cefotetan / administration & dosage,  therapeutic use*
Colon / surgery*
Drug Administration Schedule
Middle Aged
Piperacillin / administration & dosage,  therapeutic use*
Premedication / methods*
Prospective Studies
Rectum / surgery*
Surgical Wound Infection / prevention & control*
Reg. No./Substance:
61477-96-1/Piperacillin; 69712-56-7/Cefotetan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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