Document Detail

Prospective cohort study on surgical wounds comparing a polyhexanide-containing biocellulose dressing with a dialkyl-carbamoyl-chloride-containing hydrophobic dressing.
MedLine Citation:
PMID:  22914037     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : Postsurgery dressing changes in diabetic foot amputation wounds and surgical wounds healing by secondary intention are often conducted in the operating room under general anesthesia. A prospective comparative cohort study was performed in 60 patients (n = 60: n = 30/n = 30) with secondary-intention surgical wounds (82% had forefoot and/or digit[s] amputations) to compare 2 different dressing types.
METHOD: : Patients at the study center gave informed written consent, after which they were randomly allocated to one of the treatment groups. Group A received a biocellulose dressing with polyhexanide, and group B a hydrophobic dressing with dialkyl-carbamoyl-chloride. In both groups, gauze was used as secondary dressing and fixed with a film dressing. One day after surgery, the dressings were removed by the surgeon and patient-reported pain and dressing adherence/integrity were evaluated. The number of patients that required general anesthesia was determined during the procedure and afterward.
RESULTS: : All patients (n = 60; n = 30/n = 30) were included in the intention-to-treat analysis. Pain levels in group A were significantly (t (59) = 4.026, P < .000) lower upon dressing removal, when compared with group B; in group A, n = 21 reported no pain versus n = 8 (26%) for group B. In group A, the dressing adhered in 7 subjects (23%) versus n = 27 (90%) of cases in group B (P = .000). No anesthesia was required for the patients in group A, contrary to group B, where 16% of patients received general anesthesia for dressing removal.
CONCLUSION: : Pain levels were significantly lower and the dressing adhered significantly less in group A, compared with group B, demonstrating a better quality of life for the patients in group A.
Anna Marie Nielsen; Anneke Andriessen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in skin & wound care     Volume:  25     ISSN:  1538-8654     ISO Abbreviation:  Adv Skin Wound Care     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100911021     Medline TA:  Adv Skin Wound Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  409-13     Citation Subset:  N    
Anna Marie Nielsen, MD, works at the University Center for Wound Healing, Odense University Hospital, Odense, Denmark. Anneke Andriessen, PhD, RN, PA, is Owner of Andriessen Consultants, Malden, The Netherlands, and is Visiting Professor for St Radboud Academy, University Hospital, Nijmegen, The Netherlands.
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