Document Detail


Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages.
MedLine Citation:
PMID:  19382251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although persistent transmission of hepatitis C virus (HCV) from infected mothers to their infants is reported in 4-8%, transient HCV perinatal infection also occurs. This prospective cohort study determined perinatal HCV infection- and early and late clearance-rates in 1,863 mother-infant pairs in rural Egyptian villages. This study found 15.7% and 10.9% of pregnant women had HCV antibodies (anti-HCV) and HCV-RNA, respectively. Among 329 infants born of these mothers, 33 (10.0%) tested positive for both anti-HCV and HCV-RNA 2 months following birth-29 (12.5%) having HCV-RNA positive mothers and 4 (with transient infections) having mothers with only anti-HCV. Fifteen remained HCV-RNA positive at one and/or 2 years (persistent infections), while 18 cleared both virus and antibody by 1 year (transient infections). Among the 15 persistent cases, 7 cleared their infections by 2 or 3 years. At 2- to 6- and at 10- to 12-month maternally acquired anti-HCV was observed in 80% and 5% of infants, respectively. Four perinatally infected and one transiently infected infant were confirmed to be infected by their mothers by the sequence similarity of their viruses. Viremia was 155-fold greater in mothers of infants with persistent than mothers of infants with transient infections. Maternal-infant transmission of HCV is more frequent than generally reported. However, both early and late clearance of infection frequently occurs and only 15 (4.6%) and 8 (2.4%) infants born of HCV-RNA positive mothers had detectable HCV-RNA at one and 2-3 years of age. Investigating how infants clear infection may provide important information about protective immunity to HCV.
Authors:
Fatma M Shebl; Samer S El-Kamary; Doa'a A Saleh; Mohamed Abdel-Hamid; Nabiel Mikhail; Alif Allam; Hanaa El-Arabi; Ibrahim Elhenawy; Sherif El-Kafrawy; Mai El-Daly; Sahar Selim; Ayman Abd El-Wahab; Mohamed Mostafa; Soraya Sharaf; Mohamed Hashem; Scott Heyward; O Colin Stine; Laurence S Magder; Sonia Stoszek; G Thomas Strickland
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of medical virology     Volume:  81     ISSN:  1096-9071     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-06-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1024-31     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and Preventive Medicine or Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Cohort Studies
Egypt
Female
Genotype
Hepacivirus / classification,  genetics,  isolation & purification*
Hepatitis C / transmission*
Hepatitis C Antibodies / blood
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical*
Male
Pregnancy
Pregnancy Complications, Infectious / virology*
Prospective Studies
RNA, Viral / blood
Rural Population
Sequence Analysis, DNA
Time Factors
Grant Support
ID/Acronym/Agency:
1U01 HD39164/HD/NICHD NIH HHS; R01 DA013324-08/DA/NIDA NIH HHS; R01 DA13324/DA/NIDA NIH HHS; U01 AI-58372/AI/NIAID NIH HHS; U01 AI058372-05/AI/NIAID NIH HHS; U01 HD039164-04/HD/NICHD NIH HHS; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Hepatitis C Antibodies; 0/RNA, Viral
Comments/Corrections

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