| Prospective coding for objects in primate prefrontal cortex. | |
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MedLine Citation:
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PMID: 10377358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined neural activity in prefrontal (PF) cortex of monkeys performing a delayed paired associate task. Monkeys were cued with a sample object. Then, after a delay, a test object was presented. If the test object was the object associated with the sample during training (i.e., its target), they had to release a lever. Monkeys could bridge the delay by remembering the sample (a sensory-related code) and/or thinking ahead to the expected target (a prospective code). Examination of the monkeys' behavior suggested that they were relying on a prospective code. During and shortly after sample presentation, neural activity in the lateral PF cortex primarily reflected the sample. Toward the end of the delay, however, PF activity began to reflect the anticipated target, which indicated a prospective code. These results provide further confirmation that PF cortex does not simply buffer incoming visual inputs, but instead selectively processes information relevant to current behavioral demands, even when this information must be recalled from long-term memory. |
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Authors:
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G Rainer; S C Rao; E K Miller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 19 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-07-15 Completed Date: 1999-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5493-505 Citation Subset: IM; S |
Affiliation:
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Department of Brain and Cognitive Sciences, Center for Learning and Memory, and RIKEN-MIT Neuroscience Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Behavior, Animal Cell Count Conditioning (Psychology) Cues Female Macaca mulatta Male Memory, Short-Term Mental Processes / physiology* Mental Recall Neurons / cytology, physiology Photic Stimulation Prefrontal Cortex / cytology, physiology* Psychomotor Performance Reaction Time Time Factors Visual Perception / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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