Document Detail

Prospective coding for objects in primate prefrontal cortex.
MedLine Citation:
PMID:  10377358     Owner:  NLM     Status:  MEDLINE    
We examined neural activity in prefrontal (PF) cortex of monkeys performing a delayed paired associate task. Monkeys were cued with a sample object. Then, after a delay, a test object was presented. If the test object was the object associated with the sample during training (i.e., its target), they had to release a lever. Monkeys could bridge the delay by remembering the sample (a sensory-related code) and/or thinking ahead to the expected target (a prospective code). Examination of the monkeys' behavior suggested that they were relying on a prospective code. During and shortly after sample presentation, neural activity in the lateral PF cortex primarily reflected the sample. Toward the end of the delay, however, PF activity began to reflect the anticipated target, which indicated a prospective code. These results provide further confirmation that PF cortex does not simply buffer incoming visual inputs, but instead selectively processes information relevant to current behavioral demands, even when this information must be recalled from long-term memory.
G Rainer; S C Rao; E K Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  19     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-07-15     Completed Date:  1999-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5493-505     Citation Subset:  IM; S    
Department of Brain and Cognitive Sciences, Center for Learning and Memory, and RIKEN-MIT Neuroscience Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
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MeSH Terms
Action Potentials
Behavior, Animal
Cell Count
Conditioning (Psychology)
Macaca mulatta
Memory, Short-Term
Mental Processes / physiology*
Mental Recall
Neurons / cytology,  physiology
Photic Stimulation
Prefrontal Cortex / cytology,  physiology*
Psychomotor Performance
Reaction Time
Time Factors
Visual Perception / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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