| Prospective, blinded comparison of helical CT and CT arterial portography in the assessment of hepatic metastasis from colorectal carcinoma. | |
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MedLine Citation:
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PMID: 16855806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This prospective blinded comparison of helical CT and helical CT arterial portography aimed to detect liver metastasis from colorectal carcinoma. METHODS AND MATERIALS: 50 patients with colorectal carcinoma were evaluated comparing helical CT with helical CT arterial portography. Each imaging study was evaluated on a 5-point ROC scale by radiologists blinded to the other imaging findings, and the results were compared, with the surgical and pathologic findings as the gold standard. RESULTS: Of the 127 lesions found at pathology identified as metastatic colorectal cancer, helical CT correctly identified 85 (69%) and CT portography 96 (76%). When subgroups with lesions <3 cm (48 patients) and patients with maximum tumor size <3 cm (18 patients) were considered, CT portography was always better than helical CT in terms of sensitivity, specificity, positive predictive value, and negative predictive value. ROC analysis adjusting for multiple lesions per patient revealed significantly greater area under the curve (AUC) for the subgroup of lesions <3 cm (CT-AUC of 77% and CT portography AUC of 81%; P = 0.002). CONCLUSIONS: For identification of large metastases, helical CT and CT portography have similar yield. However, for detection of small liver metastases, CT portography remains superior for lesion detectability. |
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Authors:
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L Schwartz; L Brody; K Brown; A Covey; S Tuorto; M Mazumdar; E Riedel; W Jarnagin; G Getrajdman; Y Fong |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: World journal of surgery Volume: 30 ISSN: 0364-2313 ISO Abbreviation: World J Surg Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-26 Completed Date: 2006-12-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7704052 Medline TA: World J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1892-9; discussion 1900-1 Citation Subset: IM |
Affiliation:
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Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Colorectal Neoplasms
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pathology*,
radiography* Diagnosis, Differential Female Follow-Up Studies Hepatectomy Humans Liver Neoplasms / radiography*, secondary*, surgery Male Middle Aged Neoplasm Staging / methods Portography / methods* Prospective Studies Reproducibility of Results Sensitivity and Specificity Tomography, Spiral Computed* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA061524-06/CA/NCI NIH HHS; R01 CA072632-03/CA/NCI NIH HHS; R01 CA075416-03/CA/NCI NIH HHS; R01CA61524/CA/NCI NIH HHS; R01CA72632/CA/NCI NIH HHS; R01CA75416/CA/NCI NIH HHS |
| Comments/Corrections | |
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