Document Detail

Prospective association between lipid soluble antioxidants and coronary heart disease in men. The Multiple Risk Factor Intervention Trial.
MedLine Citation:
PMID:  9457009     Owner:  NLM     Status:  MEDLINE    
A nested case-control study was performed using participants enrolled in the Multiple Risk Factor Intervention Trial (MRFIT). The cases involved nonfatal myocardial infarction or death from coronary heart disease. Serum samples (n = 734) obtained at baseline and frozen for approximately 20 years were analyzed for the antioxidants, carotenoids, retinol, and alpha-, gamma-, and total tocopherol. The concentrations of antioxidants were in the expected range and their association with low density lipoprotein (LDL) cholesterol reflected their absorption and transport mechanisms. Among nonsmokers, the odds ratios (95% confidence intervals (CI)) for quartile IV versus quartile I were 1.40 (0.40-4.89), 0.77 (0.20-2.96), 1.45 (0.38-5.56), 2.34 (0.56-9.81), and 2.40 (0.52-11.07) for retinol, total carotenoids, and alpha-, gamma-, and total tocopherol, respectively. The equivalent odds ratios (95% CI) for smokers were 0.90 (0.34-2.41), 0.66 (0.23-1.84), 0.67 (0.21-2.13), 2.04 (0.88-4.73), and 0.52 (0.16-1.67), respectively. This analysis of antioxidant concentrations by quartiles indicated no significant association of antioxidant levels with the risk of coronary disease death or nonfatal myocardial infarction.
R W Evans; B J Shaten; B W Day; L H Kuller
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  American journal of epidemiology     Volume:  147     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-13     Completed Date:  1998-02-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  180-6     Citation Subset:  IM    
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA.
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MeSH Terms
Antioxidants / analysis*
Carotenoids / blood*
Cohort Studies
Coronary Disease / blood*
Middle Aged
Myocardial Infarction / blood*
Prospective Studies
Statistical Distributions
Vitamin A / blood*
Vitamin E / blood*
Grant Support
Reg. No./Substance:
0/Antioxidants; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 36-88-4/Carotenoids

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