Document Detail


Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: a preliminary report.
MedLine Citation:
PMID:  9285608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twelve consecutive patients with severe spasticity and hypertonia following acquired brain injury were treated with continuous intrathecal infusion of baclofen via an implanted, programmable infusion pump-catheter system for a minimum of 3 months. In every case intrathecal baclofen therapy resulted in a statistically significant reduction in upper- and lower-extremity tone, spasm frequency, and reflexes, contributing to improved functional abilities. There were no untoward side effects or complications associated with treatment. This preliminary assessment indicates that intrathecal administration of baclofen is effective in treating the disabling spasticity caused by acquired brain injury in selected patients.
Authors:
J M Meythaler; A McCary; M N Hadley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  87     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-09-16     Completed Date:  1997-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine, Birmingham 35294, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Baclofen / administration & dosage*
Brain Injuries / complications*
Female
Humans
Infusions, Parenteral
Injections, Spinal
Male
Muscle Relaxants, Central / administration & dosage*
Muscle Spasticity / drug therapy*,  etiology
Prospective Studies
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
0/Muscle Relaxants, Central; 1134-47-0/Baclofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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