Document Detail


Prospective study of vinorelbine and capecitabine combination therapy in Chinese patients with metastatic breast cancer pretreated with anthracyclines and taxanes.
MedLine Citation:
PMID:  20720418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: This phase II study prospectively evaluated the feasibility of vinorelbine in combination with capecitabine in Chinese patients with metastatic breast cancer (MBC) pretreated with anthracyclines and taxanes.
METHODS: Vinorelbine (25 mg/m(2) intravenous infusion on days 1 and 8) and capecitabine (1,000 mg/m(2) b.i.d., days 1-14) were administered to eligible MBC patients previously treated with anthracyclines and taxanes every 3 weeks for up to 6 cycles, until disease progression or unacceptable toxicity. The primary endpoint was objective response.
RESULTS: Seventy-two patients were enrolled. In total, 297 cycles were given (median 4 cycles, range 2-6). The overall response rate was 45.8% (95% CI 34.2-57.4%), including 5 complete (6.9%) and 28 partial responses (38.9%). With median follow-up of 22 months, median time to progression was 7.7 months (95% CI 5.5-10.0) and median survival was 26.1 months (95% CI 19.6-32.6). The response rate was 53.8% in patients resistant to anthracyclines and taxanes combination. The most common hematologic adverse events were leukopenia (81.9%) with grade 3/4 incidence of 41.7%; nausea was the most frequent non-hematologic toxicity (62.5%). Hand-foot syndrome occurred in 12.5% of patients, and diarrhea was rare.
CONCLUSIONS: Capecitabine 1,000 mg/m(2) b.i.d. combined with vinorelbine 25 mg/m(2) is an effective and safe treatment for MBC patients, no matter if anthracycline and taxane pretreated or resistant.
Authors:
Ying Fan; Binghe Xu; Peng Yuan; Jiayu Wang; Fei Ma; Qing Li; Pin Zhang; Qiao Li; Ruigang Cai
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Publication Detail:
Type:  Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-18
Journal Detail:
Title:  Chemotherapy     Volume:  56     ISSN:  1421-9794     ISO Abbreviation:  Chemotherapy     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-12-13     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  340-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anthracyclines / therapeutic use*
Antibiotics, Antineoplastic / administration & dosage,  adverse effects
Antimetabolites, Antineoplastic / administration & dosage,  adverse effects
Antineoplastic Agents, Phytogenic / administration & dosage,  adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Breast Neoplasms / drug therapy*,  pathology
Deoxycytidine / administration & dosage,  adverse effects,  analogs & derivatives*
Disease Progression
Drug Resistance, Neoplasm
Female
Fluorouracil / administration & dosage,  adverse effects,  analogs & derivatives*
Humans
Neoplasm Metastasis
Remission Induction
Taxoids / therapeutic use*
Treatment Outcome
Vinblastine / administration & dosage,  adverse effects,  analogs & derivatives*
Young Adult
Chemical
Reg. No./Substance:
0/Anthracyclines; 0/Antibiotics, Antineoplastic; 0/Antimetabolites, Antineoplastic; 0/Antineoplastic Agents, Phytogenic; 0/Taxoids; 51-21-8/Fluorouracil; 6804DJ8Z9U/capecitabine; 865-21-4/Vinblastine; 951-77-9/Deoxycytidine; Q6C979R91Y/vinorelbine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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