| Prospective study of spinal anomalies in children with infantile hemangiomas of the lumbosacral skin. | |
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MedLine Citation:
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PMID: 20828712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To prospectively evaluate a cohort of patients with infantile hemangioma in the midline lumbosacral region for spinal anomalies to determine the positive predictive value of infantile hemangioma for occult spinal anomalies and to make evidence-based recommendations for screening. STUDY DESIGN: A multicenter prospective cohort study was performed at 9 Hemangioma Investigator Group sites. RESULTS: Intraspinal abnormalities were detected in 21 of 41 study participants with a lumbosacral infantile hemangioma who underwent a magnetic resonance imaging evaluation. The relative risk for all patients with lumbosacral infantile hemangiomas for spinal anomalies was 640 (95% confidence interval [CI], 404-954), and the positive predictive value of infantile hemangioma for spinal dysraphism was 51.2%. Ulceration of the hemangioma was associated with a higher risk of having spinal anomalies. The presence of additional cutaneous anomalies also was associated with a higher likelihood of finding spinal anomalies; however, 35% of the infants with isolated lumbosacral infantile hemangiomas had spinal anomalies, with a relative risk of 438 (95% CI, 188-846). The sensitivity for ultrasound scanning to detect spinal anomalies in this high-risk group was poor at 50% (95% CI, 18.7%-81.3%), with a specificity rate of 77.8% (95% CI, 40%-97.2%). CONCLUSIONS: Infants and children with midline lumbosacral infantile hemangiomas are at increased risk for spinal anomalies. Screening magnetic resonance imaging is recommended for children with these lesions. |
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Authors:
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Beth A Drolet; Sarah L Chamlin; Maria C Garzon; Denise Adams; Eulalia Baselga; Anita N Haggstrom; Kristen E Holland; Kimberly A Horii; Anna Juern; Anne W Lucky; Anthony J Mancini; Catherine McCuaig; Denise W Metry; Kimberly D Morel; Brandon D Newell; Amy J Nopper; Julie Powell; Ilona J Frieden |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2010-09-09 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 157 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 789-94 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA. drolet@mcw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Congenital Abnormalities / epidemiology Female Hemangioma / complications* Humans Infant Infant, Newborn Lumbosacral Region Male Prospective Studies Skin Neoplasms / complications* Spine / abnormalities* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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