Document Detail


Prospective study of particulate air pollution exposures, subclinical atherosclerosis, and clinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air).
MedLine Citation:
PMID:  23043127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) was initiated in 2004 to investigate the relation between individual-level estimates of long-term air pollution exposure and the progression of subclinical atherosclerosis and the incidence of cardiovascular disease (CVD). MESA Air builds on a multicenter, community-based US study of CVD, supplementing that study with additional participants, outcome measurements, and state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, and black carbon. More than 7,000 participants aged 45-84 years are being followed for over 10 years for the identification and characterization of CVD events, including acute myocardial infarction and other coronary artery disease, stroke, peripheral artery disease, and congestive heart failure; cardiac procedures; and mortality. Subcohorts undergo baseline and follow-up measurements of coronary artery calcium using computed tomography and carotid artery intima-medial wall thickness using ultrasonography. This cohort provides vast exposure heterogeneity in ranges currently experienced and permitted in most developed nations, and the air monitoring and modeling methods employed will provide individual estimates of exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand and reduce uncertainty in health effect estimation regarding long-term exposure to air pollution and CVD.
Authors:
Joel D Kaufman; Sara D Adar; Ryan W Allen; R Graham Barr; Matthew J Budoff; Gregory L Burke; Adrian M Casillas; Martin A Cohen; Cynthia L Curl; Martha L Daviglus; Ana V Diez Roux; David R Jacobs; Richard A Kronmal; Timothy V Larson; Sally Lee-Jane Liu; Thomas Lumley; Ana Navas-Acien; Daniel H O'Leary; Jerome I Rotter; Paul D Sampson; Lianne Sheppard; David S Siscovick; James H Stein; Adam A Szpiro; Russell P Tracy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-04
Journal Detail:
Title:  American journal of epidemiology     Volume:  176     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-01-14     Revised Date:  2014-01-16    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  825-37     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Air Pollutants / analysis,  toxicity*
Air Pollution / adverse effects*,  analysis,  statistics & numerical data
Atherosclerosis / chemically induced,  epidemiology*
Cardiovascular Diseases / chemically induced,  epidemiology*
Carotid Intima-Media Thickness
Environmental Exposure / adverse effects*,  analysis
Female
Health Status
Humans
Incidence
Longitudinal Studies
Male
Middle Aged
Nitrogen Oxides / analysis,  toxicity
Particulate Matter / analysis,  toxicity*
Prospective Studies
Risk Factors
Smoking / epidemiology
Socioeconomic Factors
Soot / analysis,  toxicity
Time Factors
Tomography, X-Ray Computed
United States / epidemiology
Grant Support
ID/Acronym/Agency:
K24 ES013195/ES/NIEHS NIH HHS; N01 HC-95159/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; P30 DK063491/DK/NIDDK NIH HHS; R01HL071051/HL/NHLBI NIH HHS; R01HL071205/HL/NHLBI NIH HHS; R01HL071250/HL/NHLBI NIH HHS; R01HL0712502/HL/NHLBI NIH HHS; R01HL071251/HL/NHLBI NIH HHS; R01HL071252/HL/NHLBI NIH HHS; R01HL071258/HL/NHLBI NIH HHS; R01HL071259/HL/NHLBI NIH HHS; RR-024156/RR/NCRR NIH HHS; UL1 TR000124/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Nitrogen Oxides; 0/Particulate Matter; 0/Soot
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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