| Prospective study of particulate air pollution exposures, subclinical atherosclerosis, and clinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). | |
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MedLine Citation:
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PMID: 23043127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) was initiated in 2004 to investigate the relation between individual-level estimates of long-term air pollution exposure and the progression of subclinical atherosclerosis and the incidence of cardiovascular disease (CVD). MESA Air builds on a multicenter, community-based US study of CVD, supplementing that study with additional participants, outcome measurements, and state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, and black carbon. More than 7,000 participants aged 45-84 years are being followed for over 10 years for the identification and characterization of CVD events, including acute myocardial infarction and other coronary artery disease, stroke, peripheral artery disease, and congestive heart failure; cardiac procedures; and mortality. Subcohorts undergo baseline and follow-up measurements of coronary artery calcium using computed tomography and carotid artery intima-medial wall thickness using ultrasonography. This cohort provides vast exposure heterogeneity in ranges currently experienced and permitted in most developed nations, and the air monitoring and modeling methods employed will provide individual estimates of exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand and reduce uncertainty in health effect estimation regarding long-term exposure to air pollution and CVD. |
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Authors:
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Joel D Kaufman; Sara D Adar; Ryan W Allen; R Graham Barr; Matthew J Budoff; Gregory L Burke; Adrian M Casillas; Martin A Cohen; Cynthia L Curl; Martha L Daviglus; Ana V Diez Roux; David R Jacobs; Richard A Kronmal; Timothy V Larson; Sally Lee-Jane Liu; Thomas Lumley; Ana Navas-Acien; Daniel H O'Leary; Jerome I Rotter; Paul D Sampson; Lianne Sheppard; David S Siscovick; James H Stein; Adam A Szpiro; Russell P Tracy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-10-04 |
Journal Detail:
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Title: American journal of epidemiology Volume: 176 ISSN: 1476-6256 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-29 Completed Date: 2013-01-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 825-37 Citation Subset: IM |
Affiliation:
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Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, USA. joel@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Air Pollutants / analysis, toxicity* Air Pollution / adverse effects*, analysis, statistics & numerical data Atherosclerosis / chemically induced, epidemiology* Cardiovascular Diseases / chemically induced, epidemiology* Carotid Intima-Media Thickness Environmental Exposure / adverse effects*, analysis Female Health Status Humans Incidence Longitudinal Studies Male Middle Aged Nitrogen Oxides / analysis, toxicity Particulate Matter / analysis, toxicity* Prospective Studies Risk Factors Smoking / epidemiology Socioeconomic Factors Soot / analysis, toxicity Time Factors Tomography, X-Ray Computed United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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K24 ES013195/ES/NIEHS NIH HHS; N01 HC-95159/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; R01HL071051/HL/NHLBI NIH HHS; R01HL071205/HL/NHLBI NIH HHS; R01HL071250/HL/NHLBI NIH HHS; R01HL0712502/HL/NHLBI NIH HHS; R01HL071251/HL/NHLBI NIH HHS; R01HL071252/HL/NHLBI NIH HHS; R01HL071258/HL/NHLBI NIH HHS; R01HL071259/HL/NHLBI NIH HHS; RR-024156/RR/NCRR NIH HHS; UL1 TR000124/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Nitrogen Oxides; 0/Particulate Matter; 0/Soot |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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