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Prospective study of the modified atkins diet in combination with a ketogenic liquid supplement during the initial month.
MedLine Citation:
PMID:  20833798     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The modified Atkins diet is a high-fat, low-carbohydrate treatment for intractable childhood epilepsy. As data suggest that a stricter diet onset can be more effective, we added a ketogenic supplement to the modified Atkins diet during its initial month. Thirty children with intractable epilepsy were prospectively started on the modified Atkins diet in combination with a daily 400-calorie KetoCal( ®) shake. At 1 month, 24 (80%) children had >50% seizure reduction, of which 11 (37%) had >90% seizure reduction. There was no significant loss of efficacy during the second month after KetoCal(®) was discontinued. The use of this ketogenic supplement increased daily fat intake and thus the ketogenic ratio (1.8:1 versus 1.0:1 in the modified Atkins diet alone, P = .0002), but did not change urinary or serum ketosis. The addition of a ketogenic supplement to the modified Atkins diet during its initial month appears to be beneficial.
Authors:
Eric H Kossoff; Jennifer L Dorward; Zahava Turner; Paula L Pyzik
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Publication Detail:
Type:  Journal Article     Date:  2010-09-10
Journal Detail:
Title:  Journal of child neurology     Volume:  26     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Affiliation:
The John M. Freeman Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD. ekossoff@jhmi.edu.
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