Document Detail


Prospective study of maternal mid-pregnancy 25-hydroxyvitamin D level and early childhood respiratory disorders.
MedLine Citation:
PMID:  24134527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Studies suggest that prenatal vitamin D status may be inversely associated with lower respiratory tract infections (LRTIs) early in life. Studies of prenatal vitamin D status and development of asthma have inconsistent findings.
METHODS: We examined the associations of maternal mid-pregnancy 25-hydroxyvitamin D [25(OH)D] level with the frequency of LRTIs by 36 months and with current asthma at 36 months using the Norwegian Mother and Child Cohort Study. Maternal plasma 25(OH)D level was measured using liquid chromatography-tandem mass spectrometry. Respiratory disorders were evaluated by maternal report through questionnaires. LRTIs were analysed in a random sample of 1248 children. Asthma was analysed using a case-control design, including 489 cases and 1183 controls. Multivariable generalised linear models calculated adjusted measures of association.
RESULTS: The median gestational week of sample collection was 18 weeks (range 9, 35). The mean 25(OH)D level was 73.7 nmol/L (standard deviation 23.7). Higher maternal mid-pregnancy 25(OH)D level was associated with a reduced risk of three or more LRTIs by 36 months vs. none, adjusted risk ratio 0.74 [95% confidence interval (CI): 0.58, 0.93] per 20 nmol/L increase. Associations were similar when examining the frequency of LRTIs by 18 months, and the frequency of LRTIs between 18 and 36 months. Maternal mid-pregnancy 25(OH)D level was not significantly associated with current asthma at 36 months, adjusted odds ratio 0.91 [95% CI 0.81, 1.02] per 20 nmol/L increase.
CONCLUSIONS: Higher maternal mid-pregnancy 25(OH)D level was associated with a modestly reduced risk of recurrent LRTIs by 36 months, but was not associated with current asthma at 36 months.
Authors:
Maria C Magnus; Lars C Stene; Siri E Håberg; Per Nafstad; Hein Stigum; Stephanie J London; Wenche Nystad
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-08-20
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  27     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-18     Completed Date:  2014-07-17     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  532-41     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / epidemiology*,  etiology
Case-Control Studies
Child
Chromatography, Liquid
Female
Humans
Norway
Pregnancy
Prospective Studies
Questionnaires
Respiratory Tract Infections / epidemiology*,  etiology
Risk Factors
Tandem Mass Spectrometry
Vitamin D / analogs & derivatives*,  blood
Vitamin D Deficiency / blood*,  complications
Grant Support
ID/Acronym/Agency:
1 UO1 NS047537-01/NS/NINDS NIH HHS; 2 UO1 NS 047537-06A1/NS/NINDS NIH HHS; ES049019/ES/NIEHS NIH HHS; U01 NS047537/NS/NINDS NIH HHS; ZIA ES049019-17/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections
Erratum In:
Paediatr Perinat Epidemiol. 2014 May;28(3):276

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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