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Prospective Study of the Frequency of Hepatic Hemangiomas in Infants with Multiple Cutaneous Infantile Hemangiomas.
MedLine Citation:
PMID:  21517952     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
  Multiple cutaneous infantile hemangiomas have been associated with hepatic hemangiomas. Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. The aim of this study was to determine the frequency with which hepatic hemangiomas occur in infants with five or more cutaneous infantile hemangiomas compared to those with one to four cutaneous infantile hemangiomas and to characterize the clinical features of these hepatic hemangiomas. A multicenter prospective study of children with cutaneous infantile hemangiomas was conducted at pediatric dermatology clinics at Hemangioma Investigator Groups sites in the United States, Canada, and Spain between October 2005 and December 2008. Data were collected, and abdominal ultrasonography was performed on infants younger than 6 months old with five or more cutaneous infantile hemangiomas and those with one to four cutaneous infantile hemangiomas. Twenty-four (16%) of the 151 infants with five or more cutaneous infantile hemangiomas had hepatic hemangiomas identified on abdominal ultrasound, versus none of the infants with fewer than five (p = 0.003). Two of the 24 infants with hepatic hemangiomas received treatment specifically for their hepatic hemangiomas. Infants with five or more cutaneous infantile hemangiomas have a statistically significantly greater frequency of hepatic hemangiomas than those with fewer than 5. These findings support the recommendation of five or more cutaneous infantile hemangiomas as a threshold for screening infants younger than 6 months old for hepatic hemangiomas but also demonstrate that the large majority of these infants with hepatic hemangiomas do not require treatment.
Authors:
Kimberly A Horii; Beth A Drolet; Ilona J Frieden; Eulalia Baselga; Sarah L Chamlin; Anita N Haggstrom; Kristen E Holland; Anthony J Mancini; Catherine C McCuaig; Denise W Metry; Kimberly D Morel; Brandon D Newell; Amy J Nopper; Julie Powell; Maria C Garzon;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-26
Journal Detail:
Title:  Pediatric dermatology     Volume:  -     ISSN:  1525-1470     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
Section of Dermatology, Children's Mercy Hospitals and Clinics, Kansas City, Missouri Departments of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin Department of Dermatology, University of California at San Francisco, San Francisco, California Department of Dermatology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain Departments of Pediatrics and Dermatology, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois Departments of Dermatology and Pediatrics, Indiana University, Indianapolis, Indiana Division of Dermatology in Pediatrics, University of Montreal, Sainte Justine Hospital, Montreal, Quebec, Canada Department of Dermatology, Baylor College of Medicine, Houston, Texas Departments of Dermatology and Pediatrics, Columbia University, New York, New York.
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