Document Detail

A prospective study examining the incidence of bacteriuria and urinary tract infection after shock wave lithotripsy with targeted antibiotic prophylaxis.
MedLine Citation:
PMID:  23276509     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Controversy exists regarding antibiotic prophylaxis before shock wave lithotripsy. The AUA (American Urological Association) guideline recommends universal antibiotic prophylaxis, whereas the EAU (European Association of Urology) guideline recommends prophylaxis only for select patients. We evaluated the use of targeted antibiotic prophylaxis in preventing urinary tract infections in patients undergoing shock wave lithotripsy.
MATERIALS AND METHODS: A prospective single cohort study was performed during 6 months with patients undergoing shock wave lithotripsy. All patients underwent urine dipstick and culture before shock wave lithotripsy. Targeted antibiotic prophylaxis was provided at the discretion of the treating urologist. All patients had a urine culture performed after shock wave lithotripsy and completed a survey documenting fevers or urinary symptoms. The primary outcome was the incidence of urinary tract infections, urosepsis and asymptomatic bacteriuria after shock wave lithotripsy. The secondary outcome was the sensitivity and specificity of urinary dipstick leukocytes and nitrites.
RESULTS: A total of 526 patients were enrolled in the study. Of the 389 patients included in the determination of the primary outcome, urinary tract infection developed in only 1 (0.3%), urosepsis did not develop in any patients and asymptomatic bacteriuria developed in 11 (2.8%). Eight (2.1%) patients were administered antibiotic prophylaxis. The specificity of urine dipstick nitrites was high (95%) while the sensitivity was poor (9.7%).
CONCLUSIONS: In our cohort study using targeted antibiotic prophylaxis the rates of urinary tract infection after shock wave lithotripsy and rates of asymptomatic bacteriuria were extremely low, with no development of urosepsis. This finding questions the need for universal antibiotic prophylaxis before shock wave lithotripsy.
R John D'A Honey; Michael Ordon; Daniela Ghiculete; Joshua D Wiesenthal; Ronald Kodama; Kenneth T Pace
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-12-28
Journal Detail:
Title:  The Journal of urology     Volume:  189     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-07-17     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2112-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Age Distribution
Antibiotic Prophylaxis / methods*
Bacteriuria / epidemiology*,  etiology,  prevention & control
Cohort Studies
Follow-Up Studies
Kidney Calculi / diagnosis,  therapy
Lithotripsy / adverse effects*,  methods
Middle Aged
Prospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Ureteral Calculi / diagnosis,  therapy
Urinary Tract Infections / epidemiology*,  etiology,  prevention & control
Urolithiasis / diagnosis,  therapy*
Comment In:
Aktuelle Urol. 2014 Mar;45(2):93-4   [PMID:  24700058 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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