Document Detail


Prospective study on circulating MicroRNAs and risk of myocardial infarction.
MedLine Citation:
PMID:  22813605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study sought to explore the association between baseline levels of microRNAs (miRNAs) (1995) and incident myocardial infarction (1995 to 2005) in the Bruneck cohort and determine their cellular origin.
BACKGROUND: Circulating miRNAs are emerging as potential biomarkers. We previously identified an miRNA signature for type 2 diabetes in the general population.
METHODS: A total of 19 candidate miRNAs were quantified by real-time polymerase chain reactions in 820 participants.
RESULTS: In multivariable Cox regression analysis, 3 miRNAs were consistently and significantly related to incident myocardial infarction: miR-126 showed a positive association (multivariable hazard ratio: 2.69 [95% confidence interval: 1.45 to 5.01], p = 0.002), whereas miR-223 and miR-197 were inversely associated with disease risk (multivariable hazard ratio: 0.47 [95% confidence interval: 0.29 to 0.75], p = 0.002, and 0.56 [95% confidence interval: 0.32 to 0.96], p = 0.036). To determine their cellular origin, healthy volunteers underwent limb ischemia-reperfusion generated by thigh cuff inflation, and plasma miRNA changes were analyzed at baseline, 10 min, 1 h, 5 h, 2 days, and 7 days. Computational analysis using the temporal clustering by affinity propagation algorithm identified 6 distinct miRNA clusters. One cluster included all miRNAs associated with the risk of future myocardial infarction. It was characterized by early (1 h) and sustained activation (7 days) post-ischemia-reperfusion injury and consisted of miRNAs predominantly expressed in platelets.
CONCLUSIONS: In subjects with subsequent myocardial infarction, differential co-expression patterns of circulating miRNAs occur around endothelium-enriched miR-126, with platelets being a major contributor to this miRNA signature.
Authors:
Anna Zampetaki; Peter Willeit; Lindsey Tilling; Ignat Drozdov; Marianna Prokopi; Jean-Marie Renard; Agnes Mayr; Siegfried Weger; Georg Schett; Ajay Shah; Chantal M Boulanger; Johann Willeit; Philip J Chowienczyk; Stefan Kiechl; Manuel Mayr
Related Documents :
12794625 - Simultaneous assessment of myocardial perfusion and function during mental stress in pa...
22541275 - Carotid intima-media thickness progression to predict cardiovascular events in the gene...
22302755 - Circulating micrornas: novel biomarkers and extracellular communicators in cardiovascul...
15691055 - Diabetes and coronary artery disease: the role of stress myocardial perfusion imaging.
9512865 - Congestive heart failure and genomic medicine: a look into the 21st century.
15325475 - Beta-blockade in the management of systolic dysfunction.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  60     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-20     Completed Date:  2012-10-05     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood*
Blood Platelets / metabolism
Case-Control Studies
Cohort Studies
Diabetes Mellitus, Type 2 / blood,  genetics
Female
Humans
Italy
Male
MicroRNAs / blood*,  genetics
Middle Aged
Myocardial Infarction / blood*,  genetics*
Proportional Hazards Models
Prospective Studies
Real-Time Polymerase Chain Reaction
Reference Values
Reperfusion Injury / blood,  genetics
Risk Assessment
Thigh / blood supply
Grant Support
ID/Acronym/Agency:
FS/08/002/24537//British Heart Foundation; SP/12/5/29574//British Heart Foundation
Chemical
Reg. No./Substance:
0/Biological Markers; 0/MIRN126 microRNA, human; 0/MIRN197 microRNA, human; 0/MIRN21 microRNA, human; 0/MIRN223 microRNA, human; 0/MIRN24 microRNA, human; 0/MicroRNAs
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2012 Jul 24;60(4):300-3   [PMID:  22813606 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Where genome meets phenome: rationale for integrating genetic and protein biomarkers in the diagnosi...
Next Document:  Modeling serum biomarkers S100 beta and neuron-specific enolase as predictors of outcome after out-o...